Publications by authors named "Marta Lanza-Perea"

Anaplasma platys is a tick-transmitted rickettsial pathogen, which is known to be the etiologic agent for cyclic thrombocytopenia in its primary canine host. Infections with this pathogen are also reported in cats, cattle and people. Similarly, Ehrlichia canis is another tick-borne rickettsial pathogen responsible for canine monocytic ehrlichiosis and is also reported to cause infections in people.

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Infections with tick-borne pathogens belonging to in various vertebrate hosts are a persistent problem resulting in nonspecific clinical signs during early infection. Diagnosis of single and multi-infections with these pathogens, causing diseases in companion/agricultural animals and people, remains a challenge. Traditional methods of diagnosis, such as microscopy and serology, have low sensitivity and specificity.

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Most of the geographically isolated island nations in the Caribbean have small populations and low gross national product. As such, many lack important medical and community services. Difficulties are compounded when attempting to care for children with special needs and genetic disorders such as Down syndrome.

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Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts.

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Background And Aim: There is currently no published information on the prevalence and antimicrobial susceptibility patterns of commensal in dogs of Grenada origin. Monitoring antimicrobial resistance helps in the empirical selection of antibiotics. This study determined the occurrence of including the O157:H7 serotype in feces of non-diarrheic dogs of Grenada origin and the antibiotic resistance pattern of the isolates.

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Article Synopsis
  • Canine transmissible venereal tumor (CTVT) is a unique cancer that has survived for thousands of years by spreading through cell transfer from one dog to another.
  • Researchers analyzed 546 CTVT exomes to create a timeline and track its global spread, discovering a specific mutational process that occurred early in its evolution but later disappeared.
  • The study found that while CTVT shows minimal ongoing positive selection and some negative selection in key genes, random genetic drift plays a major role in the long-term evolution of this cancer.
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Objective: To compare postoperative analgesia following either intraperitoneal (IP) ropivacaine or bupivacaine in dogs undergoing ovariohysterectomy (OVH) in the scope of multimodal analgesia.

Study Design: Prospective, randomized, blinded clinical study.

Animals: A total of 45 privately owned dogs undergoing OVH, aged 37 ± 28 months and weighing 11.

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Tick-borne bacteria, Ehrlichia canis, Anaplasma platys, and Ehrlichia chaffeensis are significant pathogens of dogs worldwide, and coinfections of E. canis and A. platys are common in dogs on the Caribbean islands.

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Article Synopsis
  • Canine transmissible venereal tumor (CTVT) is a unique form of cancer in dogs, dating back around 11,000 years and affecting dogs worldwide.
  • Researchers analyzed 449 complete mitochondrial DNA sequences from CTVT cases and found that mitochondrial DNA has been transferred between different hosts at least five times, creating distinct tumor groups that align with historical dog migrations.
  • The study suggests that this captured mitochondrial DNA helps drive the spread of CTVT globally and emphasizes the critical role of mitochondrial DNA in the evolution of cancer.
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To identify the tick-borne pathogens in dogs from Grenada, we conducted a serologic survey for Ehrlichia canis in 2004 (104 dogs) and a comprehensive serologic and molecular survey for a variety of tick-borne pathogens in 2006 (73 dogs). In 2004 and 2006, 44 and 32 dogs (42.3% and 43.

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