Publications by authors named "Marta Kaloper"
Mech Ageing Dev
December 2024
Article Synopsis
- The aging process involves a gradual decline in bodily functions and an increased risk of diseases, largely due to mitochondrial dysfunction, particularly from the loss of Sirtuin 3 (Sirt3).
- The study examined how the absence of Sirt3 affects mitochondrial function and cellular aging in mouse embryonic fibroblasts (MEF) when exposed to DNA damage from etoposide.
- Results showed that while male MEF were relatively resilient to stress without Sirt3, female MEF were significantly more vulnerable, highlighting Sirt3's critical role in sex-specific responses to cellular damage and potential therapeutic targets related to aging.
