Publications by authors named "Marta Jimenez-Toscano"
Purpose: To address the educational gaps and support needs of patients with low anterior resection syndrome (LARS) following rectal cancer surgery. The LARSCAT project aimed to develop comprehensive resources to better inform patients and enhance their quality of life.
Methods: A qualitative study was conducted between November 2022 and March 2023.
Purpose: To better understand immigration disparities among a Spanish Early-Onset Colorectal Cancer (SECOC) subset, according to the country of origin.
Patients And Methods: We selected 250 consecutive participants from the SECOC consortium. Data on baseline patient and tumor characteristics, family history of colorectal cancer (CRC), and follow-up were collected.
Article Synopsis
- Early detection of postoperative complications in colorectal cancer surgery can improve patient outcomes, and this study aims to identify metabolic signatures that indicate risk for severe complications.
- Researchers analyzed plasma samples from 146 patients before and after surgery, using mass spectrometry to identify 188 metabolites and their ratios, finding significant associations between metabolic changes and the severity of complications.
- Key findings showed that specific metabolite ratios, particularly kynurenine/tryptophan and lysophosphatidylcholines, could predict a patient's risk for major complications, potentially guiding early intervention strategies to enhance surgical outcomes.
"Long-term oncologic outcomes and risk factors for distant recurrence after pathologic complete response following neoadjuvant treatment for locally advanced rectal cancer. A nationwide, multicentre study".
Eur J Surg Oncol
October 2023
Background: Pathologic complete response (pCR) after multimodal treatment for locally advanced rectal cancer (LARC) is used as surrogate marker of success as it is assumed to correlate with improved oncologic outcome. However, long-term oncologic data are scarce.
Methods: This retrospective, multicentre study updated the oncologic follow-up of prospectively collected data from the Spanish Rectal Cancer Project database.
Early-onset colorectal cancer (EOCRC; age younger than 50 years) incidence has been steadily increasing in recent decades worldwide. The need for new biomarkers for EOCRC prevention strategies is undeniable. In this study, we aimed to explore whether an aging factor, such as telomere length (TL), could be a useful tool in EOCRC screening.
View Article and Find Full Text PDFBackground: Individuals with a non-syndromic family history of colorectal cancer are known to have an increased risk. There is an opportunity to prevent early-onset colorectal cancer (age less than 50 years) (EOCRC) in this population. The aim was to explore the proportion of EOCRC that is preventable due to family history of colorectal cancer.
View Article and Find Full Text PDFArticle Synopsis
- The incidence of early-onset colorectal cancer (diagnosed in individuals under 50) is on the rise globally, with distinct clinical and molecular characteristics compared to late-onset cases.
- Factors contributing to this increase may include diet, obesity, antibiotic use, and changes in gut microbiome, with most cases occurring sporadically rather than being genetically inherited.
- There is a need for tailored preventive and therapeutic approaches for early-onset colorectal cancer, as younger patients often present with more severe disease stages but similar outcomes to older patients after treatment.
Aim: The aim was to investigate the influence of distal resection margin and extent of mesorectal excision on long-term oncological outcomes.
Method: Consecutive patients with upper and middle third rectal cancer from June 2006 to February 2016 were reviewed. Patients were divided into four groups depending on the distal margin considered as a surrogate marker of the extension of mesorectal excision (Q1 ≤10 mm, Q2 11-20 mm, Q3 21-30 mm, Q4 ≥31 mm).
Objectives: To determine the incidence of incisional hernia (IH) in the extraction incision (EI) in colorectal resection for cancer. To analyze whether the location of the incision has any relationship with the incidence of hernias and whether mesh could be useful for prevention in high-risk patients.
Methods: Retrospective review of the colon and rectal surgery database from January 2015 to December 2016.
Introduction: Restoration of intestinal continuity after Hartmann's procedure is a technically difficult surgery associated with significant morbidity and mortality. This study presents the short-term results of a new approach: a transanal Hartmann's colostomy reversal assisted by laparoscopy.
Method: This is a retrospective analysis of data collected in one tertiary hospital, from October 2013 to November 2015.
Purpose: Top analize the clinic results of the implantation of a multidisciplinary protocol to maintain permeability of the arteriovenous hemodialysis grafts (AVG).
Method: Prospective recording of all interventions (radiological and surgical) on AVG dysfunction in the 1999-2007 period. The AVG stenosis were always treated by percutaneous angioplasty (PA) except stenosis recurrence in less than three months or persistence after PA.
Introduction: The juxta-anastomotic stenosis is the most frequent cause of dysfunction in radiocephalic fistulas for haemodialysis. This adversity can cause low flow or thrombosis. The appropriate treatment of these lesions is under debate.
View Article and Find Full Text PDFObjective: to analyze short-term outcomes and complications for our first fifty patients with fecal incontinence undergoing sacral root stimulation.
Patients: fifty patients with fecal incontinence receiving sacral neuromodulation in 4 hospitals are reviewed. Discussed variables include: age, sex, incontinence duration, incontinence cause, prior surgery for incontinence, Wexner scale score, anorectal manometry parameters, and endoanal ultrasonographic findings.