Postweaning Development Influences Endogenous VPAC Modulation of LTP Induced by Theta-Burst Stimulation: A Link to Maturation of the Hippocampal GABAergic System.

Long-term potentiation (LTP) induced by theta-burst stimulation (TBS) undergoes postweaning developmental changes partially linked to GABAergic circuit maturation. Endogenous vasoactive intestinal peptide (VIP) acting on its VPAC receptor strongly influences LTP induced by theta-burst stimulation (TBS), an effect dependent on GABAergic transmission. Although VPAC receptor levels are developmentally regulated during embryogenesis, their variation along postweaning development is unknown, as is the VPAC modulation of LTP or its relation to hippocampal GABAergic circuit maturation.

The genera Egmundella Stechow, 1921 and Cyclocanna Bigelow, 1918 (Cnidaria, Hydrozoa) in waters of Northwest Africa.

In this paper, we study material belonging to the hydroid genera Egmundella Stechow, 1921 and Cyclocanna Bigelow, 1918 collected off the coast of Northwest Africa, from Morocco to Guinea Bissau, between 2004 and 2012, during several international surveys. Currently, the genus Egmundella is included in the family Campanulinidae Hincks, 1869, but its taxonomic status is doubtful, since most of the life cycles of its species are unknown. A total of four species have been identified: E.

Genomically matched therapy in refractory colorectal cancer according to ESMO Scale for Clinical Actionability of Molecular Targets: experience of a comprehensive cancer centre network.

Efficiency of expanded genomic profiling (EGP) programmes in terms of final inclusion of patients in genomically matched therapies is still unknown. Fit patients with advanced and refractory colorectal cancer (CRC) were selected for an EGP programme. Next-generation sequencing (NGS) analysis from formalin-fixed paraffin-embedded tumour samples was performed.

Generation and Integrated Analysis of Advanced Patient-Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer.

Clinical management of endometrial cancer (EC) is handicapped by the limited availability of second line treatments and bona fide molecular biomarkers to predict recurrence. These limitations have hampered the treatment of these patients, whose survival rates have not improved over the last four decades. The advent of coordinated studies such as The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma (TCGA_UCEC) has partially solved this issue, but the lack of proper experimental systems still represents a bottleneck that precludes translational studies from successful clinical testing in EC patients.

Early glomerular filtration rate changes in living kidney donors and recipients: an example of renal plasticity.

Background: In living kidney transplantation there are two different individuals, a healthy donor and a renal transplant recipient. This is an excellent human model to study factors that influence kidney function in the context of reduced renal mass and the adaptation of two comparable kidneys to different metabolic demands.

Methods: We analyzed the changes in measured glomerular filtration rate (GFR, iohexol) from pretransplantation to 12 months after transplantation in 30 donor-recipient pairs.

Motivational factors controlling flavor preference learning and performance: Effects of preexposure with nutritive and nonnutritive sweeteners.

In three experiments thirsty rats were given exposure to a sweet solution (saccharin in some experiments, sucrose in others) prior to consuming a compound of the sweet substance and almond flavoring. Preference for that flavor, in a choice test of almond vs. water, was then assessed.

Planar Phase-Variation Microwave Sensors for Material Characterization: A Review and Comparison of Various Approaches.

Planar phase-variation microwave sensors have attracted increasing interest in recent years since they combine the advantages of planar technology (including low cost, low profile, and sensor integration with the associated circuitry for post-processing and communication purposes, among others) and the possibility of operation at a single frequency (thereby reducing the costs of the associated electronics). This paper reviews and compares three different strategies for sensitivity improvement in such phase-variation sensors (devoted to material characterization). The considered approaches include line elongation (through meandering), dispersion engineering (by considering slow-wave artificial transmission lines), and reflective-mode sensors based on step-impedance open-ended lines.

Hydroids (Cnidaria, Hydrozoa) from Mauritanian Coral Mounds.

Unlabelled: Agassiz, L. (1862) Contributions to the natural history of the United States of America. Vol.

Highly Sensitive Reflective-Mode Defect Detectors and Dielectric Constant Sensors Based on Open-Ended Stepped-Impedance Transmission Lines.

In this paper, reflective-mode phase-variation sensors based on open-ended stepped-impedance transmission lines with optimized sensitivity for their use as defect detectors and dielectric constant sensors are reported. The sensitive part of the sensors consists of either a 90° high-impedance or a 180° low-impedance open-ended sensing line. To optimize the sensitivity, such a sensing line is cascaded to a 90° transmission line section with either low or high characteristic impedance, resulting in a stepped-impedance transmission line configuration.

Microwave Sensors Based on Resonant Elements.

This paper highlights interest in the implementation of microwave sensors based on resonant elements, the subject of a special issue in the journal. A classification of these sensors on the basis of the operating principle is presented, and the advantages and limitations of the different sensor types are pointed out. Finally, the paper summarizes the different contributions to the special issue.

Consumers' expectations and liking of traditional and innovative pork products from European autochthonous pig breeds.

The aim of the study was to ascertain the acceptability of Traditional (T) and Innovative (IT) pork products by European consumers considering also the influence of the sensory properties. The tests were performed in Barcelona, Bologna, Toulouse and Zagreb, with products from autochthonous pig breeds Porc Negre Mallorquí (patties), Cinta Senese (dry-fermented sausages), Gascon-Noir de Bigorre (dry-cured hams) and Turopolje (dry-cured hams), respectively. The methodological approach relied on the expectancy-disconfirmation model and the assimilation theory (blind, expected and informed tests).

Using 19% of alfalfa hay in beef feedlot finishing diets did not modify meat quality but increased feed intake and ADG1.

To evaluate the effects of including extra alfalfa hay (AH) in high-concentrate diets fed to beef heifers on intake, ADG, G:F, and carcass and meat quality, we used 24 Simmental heifers (initial BW 235.6 ± 4.19 kg).

Formation of aqueous and alcoholic adducts of curcumin during its extraction.

Curcumin is a phenolic compound produced by some plants, among which Curcuma longa is the reachest in this principal curcuminoid. Curcumin is known from its lability, however, the structural curcumin transformations and the formation of hydroxy and alkoxy adducts has not been reported yet. The formation of the mentioned derivatives is favoured by an alkaline environment.

Retrospective study to identify risk factors for chronic kidney disease in children with congenital solitary functioning kidney detected by neonatal renal ultrasound screening.

To evaluate the prognostic significance of factors frequently associated with a reduction in renal mass, such as prematurity, low birth weight, and congenital anomalies of kidney and urinary tract (CAKUT), in patients with solitary functioning kidney (SFK) and investigate signs of early renal injury due to glomerular hyperfiltration damage or dysplasia in the remaining kidney.Retrospective observational study of congenital SFK diagnosed and followed at a tertiary care hospital over a period of 10 years in which 32,900 newborns underwent routine neonatal abdominal ultrasound screening. We analyzed age at diagnosis, sex, gestational age, anthropometric measurements at birth and prenatal and neonatal ultrasound findings, in addition to follow-up data corresponding to imaging findings (ultrasound, micturating cystourethrography, dimercaptosuccinic acid renal, and scintigraphy), ipsilateral CAKUT, compensatory hypertrophy, and renal injury in the form of albuminuria, blood pressure, and estimated glomerular filtration rate (eGFR).

Effect of exposure to similar flavours in sensory specific satiety: Implications for eating behaviour.

Sensory-specific satiety (SSS) refers to a decline in pleasantness of eaten foods in comparison to other non-ingested meals. Although SSS is specific to the eaten food, it can also generalize to other meals that share similar properties to the satiated food. It is possible that this phenomenon could become more specific after extensive experience, as repeated exposure to an assortment of similar food could cause perceptual learning (i.

The genus L. Agassiz, 1862 (Cnidaria, Hydrozoa) in Northwest Africa.

This paper is the result of the study of large collections of Sertulariidae Lamouroux, 1812 (Cnidaria, Hydrozoa, Hydroidolina) obtained from continental margins of Northwest Africa by several Spanish and Norwegian surveys between 2004 and 2012. Material collected from Lusitanian seamounts by the French Seamount 1 expedition and from the Great Meteor Bank by the German survey Meteor 42/3 were also examined. A total of 12 species belonging to the genus Diphasia were studied and illustrated, and four new species were described: Diphasia leonisae n.

Reduction of androstenone perception in pan-fried boar meat by different masking strategies.

Background: Consumers highly sensitive to androstenone María (AND) will probably reject meat from entire male pigs, which tends to have high levels of this hormone. To avoid this, the effect of different masking strategies (sprinkling with mixed spices or fennel, marinating and breading with garlic-parsley or curry) on the sensory parameters of pork loin chops obtained from entire animals with high levels of AND (1.0-2.

Flattening of a generalization gradient following a retention interval: Evidence for differential forgetting of stimulus features.

In two experiments, rats received exposure to a compound consisting of a solution of salt plus a distinctive flavor (A), followed by an injection of furo-doca to induce a salt need. Experiment 1, established that this procedure successfully generated a preference for flavor A in a subsequent choice test between A and water. Experiment 2 used this within-event learning effect to investigate generalization, testing the rats with both A and a novel flavor (B).

Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle.

Background: The genetic basis of muscle fat deposition in pigs is not well known. So far, we have only identified a limited number of genes involved in the absorption, transport, storage and catabolism of lipids. Such information is crucial to interpret, from a biological perspective, the results of genome-wide association analyses for intramuscular fat content and composition traits.

Molecular epidemiology of carbapenemase-producing Enterobacteriaceae infection/colonisation in a hospital in Madrid.

Introduction: A description is presented on the molecular epidemiology of carbapenemase-producing enterobacteriaceae infection in a tertiary hospital.

Material And Methods: A study was made on all the carbapenemase-producing enterobacteriaceae isolations obtained between February 2015 and March 2016 in the Hospital Universitario 12 de Octubre (Madrid). Phenotypic and molecular methods were used.

Is pancreaticoduodenectomy a safe procedure in the cirrhotic patient?

Introduction: Pancreaticoduodenectomy (PD) is usually contraindicated in chronic liver disease. The objective of the present study was to analyze PD results in cirrhotic patients, and compare them with non-cirrhotic ones.

Methods: Between 1994 and 2014 we prospectively collected all patients with a PD for periampullar neoplasms in Hospital Universitari de Bellvitge.