Publications by authors named "Marta Gallis"
Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many individuals possessing hybrid immunity, generated through a combination of vaccination and infection. Concerns have been raised that omicron breakthrough infections in triple-vaccinated individuals result in poor induction of omicron-specific immunity, and that prior SARS-CoV-2 infection is associated with immune dampening. Taking a broad and comprehensive approach, we characterize mucosal and blood immunity to spike and non-spike antigens following BA.
View Article and Find Full Text PDFThe prevalence and strength of serological responses mounted toward SARS-CoV-2 proteins other than nucleocapsid (N) and spike (S), which may be of use as additional serological markers, remains underexplored. Using high-content microscopy to assess antibody responses against full-length StrepTagged SARS-CoV-2 proteins, we found that 85% (166/196) of unvaccinated individuals with RT-PCR confirmed SARS-CoV-2 infections and 74% (31/42) of individuals infected after being vaccinated developed detectable IgG against the structural protein M, which is higher than previous estimates. Compared with N antibodies, M IgG displayed a shallower time-dependent decay and greater specificity.
View Article and Find Full Text PDFArticle Synopsis
- Researchers analyzed hospital COVID-19 transmission using viral genomic and epidemiological data from 2181 patients and staff at a UK NHS Trust during two pandemic waves.
- Findings indicated a drop in staff-to-staff transmission from 31.6% to 12.9%, while patient-to-patient transmission surged from 27.1% to 52.1%.
- Control measures effectively curbed staff infections but failed to stop rising patient transmissions; thus, better detection of hospital-acquired cases is crucial to disrupt these transmission chains.