Drug Dev Ind Pharm
April 2017
Context: The stabilization of flurbiprofen loaded poly-ɛ-caprolactone nanoparticles (FB-PɛCL-NPs) for ocular delivery under accurate freeze-drying (FD) process provides the basis for a large-scale production and its commercial development.
Objective: Optimization of the FD to improve long-term stability of ocular administration's FB-PɛCL-NPs.
Methods: FB-PɛCL-NPs were prepared by solvent displacement method with poloxamer 188 (P188) as stabilizer.
Int J Nanomedicine
February 2017
This study investigated the suspension of poly(ε-caprolactone) nanoparticles as an ocular delivery system for flurbiprofen (FB-PεCL-NPs) in order to overcome the associated problems, such as stability, sterility, tolerance, and efficacy, with two different FB-PεCL-NP formulations. The formulations were stabilized with poloxamer 188 (1.66% and 3.
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