Publications by authors named "Marta Espanol"
Background And Objectives: Data about collection efficiency 1 (CE1), which takes into account blood cell counts before and after collection, thus providing a more accurate estimate, in the collection of autologous T lymphocytes by apheresis for chimeric antigen receptor (CAR) T-cells remain scarce. We evaluated donor- and procedure-related characteristics that might influence the CE1 of lymphocytes.
Materials And Methods: We retrospectively reviewed all mononuclear cell (MNC) collections) performed for CAR T-cell manufacturing in our institution from May 2017 to June 2021 in adult patients.
Article Synopsis
- CAR therapy is a promising cancer treatment that has helped many people, especially with blood cancers.
- Even though it's been successful, there are still many things that can be improved, like how the therapy is made and how it's used in hospitals.
- This chapter talks about what changes can make CAR therapy better and how it could be used for diseases beyond just blood cancers.
There are adaptive T-cell and antibody autoimmune responses to myelin-derived peptides in multiple sclerosis (MS) and to aquaporin-4 (AQP4) in neuromyelitis optica spectrum disorders (NMOSDs). Strategies aimed at antigen-specific tolerance to these autoantigens are thus indicated for these diseases. One approach involves induction of tolerance with engineered dendritic cells (tolDCs) loaded with specific antigens.
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