Publications by authors named "Marta Epalanga"
The rapid test VIKIA HIV1/2 was evaluated in 210 Angolan subjects infected with multiple HIV-1 subtypes and complex recombinant forms and 225 seronegative individuals. All infected subjects tested positive (100% sensitivity); all seronegative subjects tested negative (100% specificity). VIKIA HIV1/2 is highly specific and sensitive even in highly complex epidemics.
View Article and Find Full Text PDFThe prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease.
View Article and Find Full Text PDFArticle Synopsis
- * A study analyzed nearly 400 sequences from HIV-1 infected patients across eight Angolan provinces and identified genetic diversity, including new sub-subtypes A5 and A6 as well as a high frequency of recombinant strains.
- * The spread of HIV in Angola may date back to 1961, influenced by historical events like the independence war, which raises significant concerns for diagnostics and treatment due to the complex genetic landscape of HIV-1 in the region.
High genetic diversity of human immunodeficiency virus type 1 in Angola.
AIDS Res Hum Retroviruses
April 2005
Article Synopsis
- * Genetic discordance was observed in 17% of samples, with different subtype classifications for the gag and env genes, highlighting the complexity of HIV-1 in this region.
- * Six unique recombination patterns were identified, with A1/H potentially representing a new circulating recombinant form, underscoring the challenges and implications for future vaccine development in Angola.