PUFA stabilizes a conductive state of the selectivity filter in IKs channels.

In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolonged QT interval on the ECG, which increases the risk of ventricular arrhythmia and sudden cardiac death. One potential therapeutical intervention for LQTS is based on targeting IKs channels to restore channel function and/or the physiological QT interval.

Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel.

Voltage-gated proton (Hv1) channels are involved in many physiological processes, such as pH homeostasis and the innate immune response. Zn is an important physiological inhibitor of Hv1. Sperm cells are quiescent in the male reproductive system due to Zn inhibition of Hv1 channels, but become active once introduced into the low-Zn-concentration environment of the female reproductive tract.