Contribution of the -455G/A polymorphism at beta-fibrinogen gene and of the Leiden mutation to hemorheological parameters in ischemic stroke patients.

Unlabelled: The concentration of plasma fibrinogen (FIB) is an important factor in the coagulation cascade and also in the determination of blood and plasma viscosity depending on both genetic and acquired factors. The -455G/A polymorphism of the beta-FIB gene is connected to the plasma concentration of FIB but the effect of Leiden mutation on hemorheological parameters is unclear. The two genetic polymorphisms were studied by polymerase chain reaction in healthy subjects and ischemic stroke cohort and the effects on the concentration of plasma FIB, whole blood and plasma viscosity of patients as well.

[Significance of Factor V gene A506G mutation (Leiden) in the pathogenesis of ischemic stroke].

Background: There are conflicting data about the role of Leiden mutation in the pathogenesis of cerebral arterial thrombosis. In order to obtain relevant data, authors investigated the prevalence of factor V Leiden (A506G) both in healthy subjects and in a subgroup of ischaemic stroke patients.

Material And Methods: Blood samples of 171 healthy persons and 254 ischaemic stroke patients were examined by PCR method for Leiden mutation.

[Issues in the care of stroke patients].

All patients having had stroke or TIA require special post-hospital care, being mainly the task of general practitioners. The number of patients surviving stroke in Hungary is approximately 30,000/year. An important focus of care is secondary prevention: antithrombotic treatment and risk factors reduction.

[Genetics of blood coagulation in young stroke patients].

Background And Purpose: The classical risk factors did not explain all the possible etiology of cerebral stroke. Genetic polymorphisms responsible for thrombophilia were implicated recently as risk factors of stroke. In this genetico-epidemiological study the author's aim was to analyse the tendency of genetic polymorphisms to cluster in a cohort of young and elderly stroke patients and in healthy subjects in Hungary.

[Investigation of insertion/deletion polymorphism of the ACE gene in stroke patients].

Introduction: This is the first Hungarian paper on the insertion/deletion polymorphism of ACE gene in stroke patients. According to literature data, the role of this polymorphism is controversial in the pathogenesis of stroke. The aim was to study the prevalence of the polymorphism in healthy persons and in stroke patients.