Publications by authors named "Marta Castellano"

Little is known about how transcranial alternating current stimulation (tACS) interacts with brain activity. Here, we investigate the effects of tACS using an intermittent tACS-EEG protocol and use, in addition to classical metrics, Lempel-Ziv-Welch complexity (LZW) to characterize the interactions between task, endogenous and exogenous oscillations. In a cross-over study, EEG was recorded from thirty participants engaged in a change-of-speed detection task while receiving multichannel tACS over the visual cortex at 10 Hz, 70 Hz and a control condition.

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Objective: The objective of this study was to test the feasibility of a combined intervention involving transcranial direct current stimulation (tDCS) on the dorsolateral prefrontal cortex (dlPFC) and cognitive training (CT). Short-term effects on food consumption, cognition, endocannabinoid (eCB) levels, and electroencephalogram (EEG) markers of future weight loss were explored.

Methods: Eighteen healthy volunteers with morbid obesity were randomized in a double-blind, placebo-controlled, parallel trial.

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REM Behavior Disorder (RBD) is now recognized as the prodromal stage of α-synucleinopathies such as Parkinson's disease (PD). In this paper, we describe deep learning models for diagnosis/prognosis derived from a few minutes of eyes-closed resting electroencephalography data (EEG) collected at baseline from idiopathic RBD patients ( = 121) and healthy controls (HC, = 91). A few years after the EEG acquisition (4±2 years), a subset of the RBD patients were eventually diagnosed with either PD ( = 14) or Dementia with Lewy bodies (DLB, = 13), while the rest remained idiopathic RBD.

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Idiopathic rapid eye movement sleep behavior disorder (RBD) is a serious risk factor for neurodegenerative processes such as Parkinson's disease (PD). We investigate the use of EEG algorithmic complexity derived metrics for its prognosis. We analyzed resting state EEG data collected from 114 idiopathic RBD patients and 83 healthy controls in a longitudinal study forming a cohort in which several RBD patients developed PD or dementia with Lewy bodies.

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The ability to integrate visual features into a global coherent percept that can be further categorized and manipulated are fundamental abilities of the neural system. While the processing of visual information involves activation of early visual cortices, the recruitment of parietal and frontal cortices has been shown to be crucial for perceptual processes. Yet is it not clear how both cortical and long-range oscillatory activity leads to the integration of visual features into a coherent percept.

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Cortical neurons are typically driven by several thousand synapses. The precise spatiotemporal pattern formed by these inputs can modulate the response of a post-synaptic cell. In this work, we explore how the temporal structure of pre-synaptic inhibitory and excitatory inputs impact the post-synaptic firing of a conductance-based integrate and fire neuron.

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