Publications by authors named "Marta Arrigoni"
Background: Congenital hypothyroidism (CH) is a preventable cause of neurodevelopmental delay in children, detectable by newborn screening (NBS) programs for CH. Since NBS for CH was started in Canada in 1974, numerous countries have successfully implemented this public health strategy. However, in 2014, only 29.
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- Precocious puberty (PP) in girls is characterized by breast development before age 8, with a diagnostic procedure using GnRH stimulation to measure LH levels, traditionally with a cutoff of 15 IU/L, but many still showed lower levels.
- The study aimed to establish a new lower LH threshold of 5 IU/L for earlier diagnosis of central precocious puberty (CPP) and assess other diagnostic parameters.
- Results indicated that girls with higher LH levels and other indicators, like growth velocity, were more likely to have axis activation, leading to the new proposed LH threshold for better diagnostic accuracy.
Background: Primary adrenal insufficiency (PAI) in childhood is a life-threatening disease most commonly due to impaired steroidogenesis. Differently from adulthood, autoimmune adrenalitis is a rare condition amongst PAI's main aetiologies and could present as an isolated disorder or as a component of polyglandular syndromes, particularly type 2. As a matter of fact, autoimmune polyglandular syndrome (APS) type 2 consists of the association between autoimmune Addison's disease, type 1 diabetes mellitus and/or Hashimoto's disease.
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