Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.

Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.

Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.

Preoperative predictors of pelvic and para-aortic lymph node metastases in cervical cancer.

Aim: This study investigated potential preoperative predictors of pelvic lymph node (PLN) and para-aortic LN (PaLN) involvement in cervical cancer (CC).

Materials And Methods: This study retrospectively analyzed 283 patients diagnosed with early (stage IA1-IIA) CC who underwent retroperitoneal LN dissection between January 1992 and February 2015. Several risk factors that are believed to influence PLN and PaLN involvement in CC were analyzed as follows: age >50 years, lymphovascular space invasion (LVSI), tumor size ≥2 cm, hemoglobin <12 g/dL, and nonsquamous cell histologic type.

Management of Vertebral Metastasis in Patients With Uterine Cervical Cancer.

Aim: We sought to identify risk factors and management options for uterine cervical cancer (UCC) patients with a vertebral metastasis (VM) treated over the course of 23 years.

Methods: Among 844 UCC patients, 18 were diagnosed with a VM. Thirty-six control patients with UCC but without recurrence were matched to these 18 in terms of stage and histological tumor type using a dependent random sampling method.

Descending necrotizing mediastinitis in the elderly patients.

Descending Necrotizing Mediastinitis (DNM) is a polymicrobic, dangerous and often fatal process, arising from head or neck infections and spreading along the deep fascial cervical planes, descending into the mediastinum. It can rapidly progress to sepsis and can frequently lead to death. It has a high mortality rate, up to 40% in the different series, as described in the literature.

Neuropsychological Assessment of Testamentary Capacity and Undue Influence.

Neuropsychologists are increasingly requested to perform assessments of testamentary capacity. This article provides an overview of the psycho-legal context in which such assessments are performed. Suggestions for an evaluative methodology for performing these evaluations with both living and deceased testators are provided.

Uncertainty of historical measurements of 131I in Hanford-area vegetation.

The Hanford Environmental Dose Reconstruction (HEDR) Project was conducted to estimate the radiation dose that individuals could have received as a result of emissions to the air and water from Hanford Site operations since 1944. The largest doses were to the human thyroid gland from 131I released into the atmosphere from Hanford facilities in the 1945-1947 time period. In support of the dose reconstruction effort, a database of historical environmental radioactivity measurements was constructed.