A high-fat diet, but not haloperidol or olanzapine administration, increases activated microglial expression in the rat brain.

This study examined the effects of chronic treatment of the antipsychotic drugs, haloperidol and olanzapine, on microglial activation in the brain. In addition, we explored the interaction of these antipsychotic drugs with normal and high-fat diet. In order to measure activated microglial expression, we used [H] PK11195 in vitro autoradiography.