Publications by authors named "Marsha Leen-Mitchell"
Article Synopsis
- A study using data from the Utah Birth Defect Network identified 91 cases of diabetic embryopathy among over 825,000 births from 2001 to 2016, highlighting the specific connection between maternal diabetes and birth defects.
- The overall prevalence of diabetes-related malformations during this period was found to be 1.1 per 10,000 births, emphasizing the importance of managing pregestational diabetes to potentially reduce these risks.
Determination of human teratogenicity by the astute clinician method: review of illustrative agents and a proposal of guidelines.
Birth Defects Res A Clin Mol Teratol
January 2009
Background: The determination that an exposure is a human teratogen is a complex process involving the application of the principles of teratology, epidemiology, biology, and clinical medicine. Shepard suggested that the "rare exposure/rare defect" or "case report method", the astute clinician model, was one approach for establishing teratogenicity. The purpose of this article is to review selected exposures with the goal of identifying principles that lead to a working proposal for the application of this approach.
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