Life-threatening chlorpromazine-induced acquired haemophilia A in a patient with a cavernous malformation involving the medulla oblongata.

Introduction: Chlorpromazine is a commonly used drug in several medical conditions associated with a wide range of side effects. Few cases of hemostatic disorder have been reported in the literature.

Case Report: A 39-year-old man had previously been diagnosed with a cavernous malformation of the medulla oblongata.

Tocilizumab for Severe Worsening COVID-19 Pneumonia: a Propensity Score Analysis.

Background: High levels of serum interleukin-6 (IL-6) correlate with disease severity in COVID-19. We hypothesized that tocilizumab (a recombinant humanized anti-IL-6 receptor) could improve outcomes in selected patients with severe worsening COVID-19 pneumonia and high inflammatory parameters.

Methods: The TOCICOVID study included a prospective cohort of patients aged 16-80 years with severe (requiring > 6 L/min of oxygen therapy to obtain Sp02 > 94%) rapidly deteriorating (increase by ≥ 3 L/min of oxygen flow within the previous 12 h) COVID-19 pneumonia with ≥ 5 days of symptoms and C-reactive protein levels > 40 mg/L.

DPP4 inhibitor-induced polyarthritis: a report of three cases.

Dipeptidyl peptidase-4 (DPP4) inhibitors are a novel therapy widespread used in type 2 diabetes mellitus. We describe 3 cases of polyarthritis which delay of appearance strongly suggests a link with DPP4 inhibitors. Three patients presented with bilateral, symmetrical, seronegative polyarthritis after introduction of DPP4 inhibitors (sitagliptine (n = 2) and vildagliptine (n = 1)).

Misrepresentation of randomized controlled trials in press releases and news coverage: a cohort study.

Background: Previous studies indicate that in published reports, trial results can be distorted by the use of "spin" (specific reporting strategies, intentional or unintentional, emphasizing the beneficial effect of the experimental treatment). We aimed to (1) evaluate the presence of "spin" in press releases and associated media coverage; and (2) evaluate whether findings of randomized controlled trials (RCTs) based on press releases and media coverage are misinterpreted.

Methods And Findings: We systematically searched for all press releases indexed in the EurekAlert! database between December 2009 and March 2010.

[Charcot's disease of the lumbosacral joint in spinal cord injury: a case report].

Objective: Comment on spinal damage in Charcot's disease.

Observation: We report on a paraplegic patient with T9 spinal cord injury who developed destructive arthropathy of the lumbosacral joint.

Discussion: Charcot's disease occurs sporadically during the progression of certain chronic neurological diseases.

[Lingual tuberculosis revealing disseminated tuberculosis].

Introduction: Tuberculous lesions of the oral cavity are uncommon. Most of cases are secondary to pulmonary disease and the primary form is rare.

Exegesis: We report the case of a 64 year-old man, smoker, presenting a chronic ulcer of the tongue, with anorexia and important weight loss.

[Pancreatic involvement in Wegener's granulomatosis: a rare and difficult diagnosis].

Introduction: Pancreatic involvement in the course of wegener's granulomatosis is rarely reported.

Exegesis: We report a case presenting as a pancreatic tumorlike lesion. We also discuss six further cases from the medical literature.

Intractable hiccup as the initial presenting feature of systemic lupus erythematosus.

An infarctus of medulla oblongata was discovered in a 44-year old man with an intractable hiccup and 10, 11th and 12th right cranial nerves palsies. Systemic lupus erythematosus (SLE) with antiphospholipid syndrome was subsequently diagnosed. Hiccup has withdrew with corticosteroid therapy and low-dose aspirin.