Mechanisms of cell damage due to mechanical impact: an in vitro investigation.

The dynamic response of cells when subjected to mechanical impact has become increasingly relevant for accurate assessment of potential blunt injuries and elucidating underlying injury mechanisms. When exposed to mechanical impact, a biological system such as the human skin, brain, or liver is rapidly accelerated, which could result in blunt injuries. For this reason, an acceleration of greater than > 150 g is the most commonly used criteria for head injury.

In Situ Visualization of Particle Motions during Wipe Sampling of Explosives and Other Trace Particulate Materials.

Surface texture tailoring has the potential to increase the effectiveness of dry particle collection wipes, as a wipe's topographical features control the intimate surface contact made with particles on the substrate (critical for van der Waals-governed adhesion). However, texture-tailoring approaches have not yet been widely explored, in part because of a lack of understanding of the specific wipe topographies and wipe/particle interactions that maximize particle collection. Here we describe an in situ optical microscopy technique that enables direct observation of micrometer-scale particle-wipe interactions occurring at the wipe-substrate interface during contact sampling.

In situ thermomechanical testing methods for micro/nano-scale materials.

The advance of micro/nanotechnology in energy-harvesting, micropower, electronic devices, and transducers for automobile and aerospace applications has led to the need for accurate thermomechanical characterization of micro/nano-scale materials to ensure their reliability and performance. This persistent need has driven various efforts to develop innovative experimental techniques that overcome the critical challenges associated with precise mechanical and thermal control of micro/nano-scale specimens during material characterization. Here we review recent progress in the development of thermomechanical testing methods from miniaturized versions of conventional macroscopic test systems to the current state of the art of in situ uniaxial testing capabilities in electron microscopes utilizing either indentation-based microcompression or integrated microsystems.