Midazolam induced cerebral cortex changes in 30-day-old mice treated from 8 to 29 days of age.

The exposure of 8 to 29-day-old mouse pups to midazolam (MDZ) produces the same type of histological alterations in the cerebral cortex as those caused in mice by exposure in utero to diazepam (DZ) from day 6 to 17 of gestation. Two groups of 10 each ICR (Harlan Mexico) strain male mice were injected: the first with a single daily MDZ dose (2.0 mg/kg/bw, s.

Midazolam administered to 8-day-old mouse pups for three weeks induces cerebellar cortex alterations.

Midazolam (MDZ) administered during the neonatal period induces histological changes in the cerebellar cortex of mouse pups. We investigated whether these changes are similar to those induced by prenatal exposure to diazepam (DZ). Two neonatal ICR-strain mouse groups were injected daily from day 8 to 29.

Motor response of 14-month-old female mice exposed to diazepam prenatally.

The response of adult female mice to diazepam (DZ) can be sculpted by the prenatal experience with the drug. Experiments were performed in ICR strain (Harlan México) mice exposed in utero to DZ. They were born from dams injected (s.

Permanent effects of prenatal exposure to diazepam on sexual behavior of male mice.

In previous work, we found effects of prenatal exposure to diazepam (DZ) on sexual behavior of adult mice. The aim of this work was to compare sexual behavior during their reproductive span of CD-1 strain male mice exposed in utero to DZ. One group of female mice was treated with DZ (2.

[Teratologic effects of benzodiazepines].

Benzodiazepines are drugs that belong to the group of minor tranquilizers. They derive from the 1-4, benzodiazepine common nucleus that was obtained by chemical synthesis and act upon the GABA receptors increasing their affinity, thus providing them with their tranquilizing, miorelaxing, and anticonvulsant properties. Due to these characteristics they have been used in a wide variety of disorders accompanied by anxiety, hyperexitability, convulsions, and muscular hypertony, as well as during pregnancy and labor.

Diazepam effect upon the microscopic structure of the mouse placenta.

CD-1 strain, female mice, aged 5 to 7 months, were mated with males of the same age. Females presenting vaginal plug were separated and randomly distributed in two groups to be treated from the 6th to 17th day of gestation. One group received single daily diazepam doses (2.

Ca2+-agonistic effects of diazepam, a benzodiazepine 1-4 derivative, on isolated mouse and guinea pig left atria.

In normal Krebs solution, diazepam (1.75X10(-4) M) increased the action potential duration in a reversible form and caused a positive inotropic effect on mouse auricular muscle (4). 2.