Publications by authors named "Marni Nishimoto"
Article Synopsis
- Regulatory T cells (T) are traditionally seen as suppressors of antitumor immunity, but their influence on immune checkpoint blockade (ICB) responses remains uncertain.
- This study used advanced sequencing techniques to analyze over 73,000 tumor-infiltrating T cells from both anti-PD-1 treated and untreated lung cancer patients, identifying 10 distinct T cell subsets, with one subset showing high expression of activation markers linked to immune suppression.
- The findings suggest that not all TIL-Ts are detrimental; a specific subset may help enhance responses to therapy, illustrating the complex role of TIL-Ts in cancer treatment.
R-spondin (RSPO) proteins amplify Wnt signaling and stimulate regeneration in a variety of tissues. To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic molecules are desired. Here, we mutated RSPO (RSPO2 F105R/F109A) to eliminate LGR binding while preserving ZNRF3/RNF43 binding and targeted the mutated RSPO to a liver specific receptor, ASGR1.
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