Publications by authors named "Marnee J Mckay"

Disorders affecting the neurological and musculoskeletal systems represent international health priorities. A significant impediment to progress in trials of new therapies is the absence of responsive, objective, and valid outcome measures sensitive to early disease changes. A key finding in individuals with neuromuscular and musculoskeletal disorders is the compositional changes to muscles, evinced by the expression of fatty infiltrates.

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Background: As the focus of classification shifts towards an evidence-based approach, it is crucial to establish a robust system that relies on valid and reliable measures of impairment to ensure legitimate and competitive opportunities for all Para athletes. However, the lack of methods that possess the necessary measurement properties for assessing impairments in Para sporting populations presents significant challenges to developing an evidence-based classification system.

Objective: This review aimed to identify and evaluate measures of impairment and activity limitation measures that have been used to assess eligible impairments in Para sport athletes for potential use in evidence-based classification.

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Article Synopsis
  • The study investigates the link between RNA alternative splicing abnormalities and physical function in children with congenital myotonic dystrophy (CDM), a severe form of myotonic dystrophy type 1 (DM1).
  • Researchers analyzed data from 82 participants, including adults with DM1 and children with CDM, assessing muscle biopsies, motor function, strength, and myotonia.
  • Results showed a significant correlation between myotonia and RNA mis-splicing in all DM1 individuals, while motor performance and strength were associated with splicing dysregulation, aiding future clinical trial designs for DM1 and CDM.
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The aim of this longitudinal case series was to describe long-term functional outcome in a group of individuals with riboflavin transporter deficiency (RTD) treated with high-dose oral riboflavin. Data were collected between 2012 to 2022. Eleven individuals with RTD were assessed at 12-month intervals for monitoring of disease progression.

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Background: Adults with physical or intellectual disability are less active than those without disability.

Objective: To review literature regarding sport participation in adults with physical or intellectual disability. Specifically, to examine characteristics of available studies including participants, interventions, outcomes, and impact.

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  • The study investigates age-related changes in thigh muscle composition, focusing on the loss of muscle mass and increase in intramuscular fat in adults aged 45-84 using data from the UK Biobank with over 50,000 participants.
  • Findings show a consistent decline in fat-free muscle volume and a rise in intramuscular fat across different age groups, with specific metrics provided for both men and women.
  • Results are significant for establishing normative values that can inform health and lifestyle recommendations related to physical activity and conditions like leg pain and bone density.
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Article Synopsis
  • - The study investigates the link between RNA alternative splicing dysregulation, a key feature of myotonic dystrophy type 1 (DM1), and physical function in children with congenital myotonic dystrophy (CDM), a severe form of the disease.
  • - Researchers combined data from 82 participants (42 adults with DM1 and 40 children with CDM) to analyze muscle biopsies and assess their myotonia, motor function, and strength, finding significant correlations between muscle performance and alternative splicing measures.
  • - The results indicate strong associations between RNA mis-splicing, muscle strength, and motor performance across all DM1 subjects, helping to develop predictive models that could guide future clinical trials for treating DM
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Aim: Selective dorsal rhizotomy (SDR) is a neurosurgical intervention used to reduce spasticity in children with cerebral palsy (CP). There is minimal relevant, evidence-based information available for Australian families and clinicians. This study aims to investigate the knowledge of people with lived experience and clinicians regarding SDR, including how they currently access information and what information they seek.

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Aim: To develop and user test an evidence-based patient decision aid for children and adolescents who are considering anterior cruciate ligament (ACL) reconstruction.

Design: Mixed-methods study describing the development of a patient decision aid.

Setting: A draft decision aid was developed by a multidisciplinary steering group (including various types of health professionals and researchers, and consumers) informed by the best available evidence and existing patient decision aids.

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Muscle strength is routinely measured in patients with neuromuscular disorders by hand-held dynamometry incorporating a wireless load cell to evaluate disease severity and therapeutic efficacy, with magnitude of effect often based on normative reference values. While several hand-held dynamometers exist, their interchangeability is unknown which limits the utility of normative data. We investigated the variability between six commercially available dynamometers for measuring the isometric muscle strength of four muscle groups in thirty healthy individuals.

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Article Synopsis
  • Proximal phalangeal fractures are common injuries in children, traditionally treated with a 5-week splinting period, even when healing is apparent at 3 weeks.
  • A study involving 80 children assessed whether a 3-week splinting duration is as effective as the standard 5-week approach by comparing total active motion in the injured digit.
  • Results indicated that early removal of the splint is just as effective, suggesting a shift in practice towards using clinical healing assessments to guide treatment in children with these fractures.
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Introduction: The rapid shift to online learning due to the COVID-19 pandemic presented challenges for physical therapy (PT) education worldwide. This article aims to explore the factors influencing the well-being of the PT faculty and department chairs involved in delivering PT programs during the initial stages of the COVID-19 pandemic.

Review Of Literature: The literature has focused on the pedagogical impacts of the rapid shift to online learning.

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Background And Aims: Riboflavin transporter deficiency (RTD) is a progressive inherited neuropathy of childhood onset, characterised clinically by pontobulbar palsy, sensory ataxia, sensorineural deafness, muscle weakness, optic atrophy and respiratory failure. A robust and responsive functional outcome measure is essential for future clinical trials of disease-modifying therapies including genetic therapies. The Charcot-Marie-Tooth disease Pediatric Scale (CMTPedS) is a well-validated outcome measure for CMT and related neuropathies, and might have utility for measuring disease progression in individuals with RTD.

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Objective: To systematically investigate the association between musculoskeletal pain during pregnancy and birth outcomes including caesarean section, newborn birthweight, newborn birth length, and gestational age at birth.

Methods: Medline, Embase, Web of Science, Cinahl and Scopus were systematically searched to identify eligible studies. Odds ratios, mean differences, and confidence intervals were used to describe results.

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Background And Objectives: Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication of , is the most common hereditary peripheral neuropathy. For participants with CMT1A, few clinical trials have been performed; however, multiple therapies have reached an advanced stage of preclinical development. In preparation for imminent clinical trials in participants with CMT1A, we have produced a Clinical Outcome Assessment (COA), known as the CMT-Functional Outcome Measure (CMT-FOM), in accordance with the FDA Roadmap to Patient-Focused Outcome Measurement to capture the key clinical end point of function.

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Objectives: To evaluate the effects of sport or physical recreation on participation, mobility and quality of life for adults living with disabilities.

Design: Systematic review with meta-analysis.

Data Sources: Six databases searched from inception to May 2022.

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Patient-reported outcome measures (PROMs) provide structured information on the patient's health experience and facilitate shared clinical decision-making. Registries that collect PROMs generate essential information about the clinical course and efficacy of interventions. Whilst PROMs are increasingly being used in adult orthopaedic registries, their use in paediatric orthopaedic registries is not well known.

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Objectives: To investigate the injury characteristics and insurance cost of anterior cruciate ligament injuries in sub-elite football players in New South Wales, Australia.

Design: Descriptive epidemiological study.

Methods: Three years of insurance records (2018-2020) was used to describe anterior cruciate ligament injury costs and characteristics.

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Objective: To develop and user-test a patient decision aid portraying the benefits and harms of non-surgical management and surgery for Achilles tendon ruptures.

Design: Mixed methods.

Setting: A draft decision aid was developed using guidance from a multidisciplinary steering group and existing patient decision aids.

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Despite emerging research questioning the long-term effect of purposeful heading on players' brain health, heading-related perspectives and behaviours of stakeholders in amateur football in Australia (a country without heading guidelines) remain unknown. This study aimed to explore the current heading-related perspectives and behaviours of football stakeholders. In total, 290 players (aged over 11 years), 54 coaches, 34 non-coaching staff and 14 medical staff completed the survey.

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Objective: Examine longitudinal changes in trunk, hip, and knee kinematics in maturing boys during an unanticipated cutting task.

Design: Prospective cohort study.

Setting: Biomechanical laboratory.

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Objectives: The primary aim of this study was to compare injury rates pre- and post-COVID-19 lockdown in sub-elite football (soccer) players by analysing the full season and the first month of each season between 2018 and 2020. Secondary aims were to describe the incidence, location and type of injuries and to compare injuries by age group and sex.

Design: Descriptive epidemiological study.

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Article Synopsis
  • The study aims to evaluate the prevalence, incidence, and impact of gradual-onset knee injuries in team ball sports through a systematic review and meta-analysis.
  • Researchers analyzed data from 49 studies that reported on various types of gradual-onset knee injuries across 15 different team ball sports, finding varying rates of prevalence and incidence.
  • The findings highlight that gradual-onset knee injuries are prevalent, with a significant burden in terms of days lost, and call for further research to explore factors like age, type of sport, and level of participation as potential predictors of these injuries.
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