Progesterone Receptor Expression Is an Independent Prognosticator in FIGO Stage I Uterine Leiomyosarcoma.

Objectives: To analyze the clinical role of hormone receptors in a large uterine sarcomas series with long-term follow-up.

Methods: Protein expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemistry was studied in tissue microarrays from 294 patients diagnosed with uterine sarcoma in Norway from 1970 to 2000 and analyzed for an association with clinicopathologic parameters and outcome.

Results: ER and PR were detected in 136 of 291 and 184 of 291 tumors (three noninformative cases each), respectively.