Publications by authors named "Marly Melo"
Safety and efficacy of three alternative regimens against relapsing Plasmodium vivax malaria in glucose 6-phosphate dehydrogenase deficient patients in the Brazilian Amazon (ALTPRIM).
Clin Infect Dis
January 2025
Background: Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed.
Methods: G6PDd participants with P.
Prevalence of glucose 6-phosphate dehydrogenase deficiency in highly malaria-endemic municipalities in the Brazilian Amazon: A region-wide screening study.
Lancet Reg Health Am
August 2022
Article Synopsis
- Difficulties in assessing glucose-6-phosphate dehydrogenase deficiency (G6PDd) in remote areas pose risks for safely using malaria treatments like primaquine and tafenoquine, due to potential hemolysis.
- A study conducted in the Brazilian Amazon from 2014 to 2018 screened nearly 15,000 males for G6PDd, revealing a 5.6% prevalence overall, with the highest rates in Acre and Amapá.
- The findings suggest that many individuals could suffer hemolysis if treated with certain anti-malarial drugs, highlighting the need for G6PDd screening to protect patients and support malaria elimination efforts.
The western Amazon basin is an important endemic area for malaria by P. vivax. In recent years, several reports showed the treatment failure with chloroquine, which can be related to resistance.
View Article and Find Full Text PDFReal-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study).
PLoS Negl Trop Dis
May 2021
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis. Although the deleterious health effects of primaquine in G6PD deficient individuals have been known for over 50 years, G6PD testing is not routinely performed before primaquine treatment in most P. vivax endemic areas.
View Article and Find Full Text PDFPerformance of an immuno-rapid malaria Pf/Pv rapid diagnostic test for malaria diagnosis in the Western Brazilian Amazon.
Rev Soc Bras Med Trop
January 2019
Introduction: Rapid diagnostic tests (RDTs) for detecting Plasmodium antigens have become increasingly common worldwide. We aimed to evaluate the accuracy of the Immuno-Rapid Malaria Pf/Pv RDT in detecting Plasmodium vivax infection compared to standard thick blood smear (TBS) under microscopy.
Methods: Hundred and eighty-one febrile patients from the hospital's regular admissions were assessed using TBS and RDT in a blinded experiment.
Sciadicleithrum juruparii n. sp. is described from the gills of the Neotropical cichlid fish Satanoperca jurupari (Heckel) caught in the Guamá River, in the delta of the Amazon River, at Belém, Pará State, Brazil.
View Article and Find Full Text PDFRaphidascaris (Sprentascaris) lanfrediae sp. nov. (Nematoda: Anisakidae) from the fish Satanoperca jurupari (Osteichthyes: Cichlidae).
Mem Inst Oswaldo Cruz
August 2011
Raphidascaris (Sprentascaris) lanfrediae sp. nov. is described from the intestine of the freshwater fish Satanoperca jurupari (Heckel) (Cichlidae) from the Guamá River, state of Pará, Brazil.
View Article and Find Full Text PDFSatanoperca jurupari (Osteichthyes: Cichlidae) is reported for the first time to be parasitized by the nematodes Procamallanus (Spirocamallanus) rarus Travassos, Artigas and Pereira, 1928, Procamallanus (Spirocamallanus) sp., larvae of Raphidascaroides sp. and Anisakidae gen.
View Article and Find Full Text PDF