Abutment Material Effect on Peri-implant Soft Tissue Color and Perceived Esthetics.

Purpose: The purpose of this study was to evaluate the effect of implant abutment material on peri-implant soft tissue color using intraoral spectrophotometric analysis and to compare the clinical outcomes with patient and clinician perception and satisfaction.

Materials And Methods: Thirty patients and four prosthodontic faculty members participated. Abutments were zirconia, gold-hued titanium, and titanium.

Association of the GGCX (CAA)16/17 repeat polymorphism with higher warfarin dose requirements in African Americans.

Objective: Little is known about genetic contributors to higher than usual warfarin dose requirements, particularly for African Americans. This study tested the hypothesis that the γ-glutamyl carboxylase (GGCX) genotype contributes to warfarin dose requirements greater than 7.5 mg/day in an African American population.

Association of apolipoprotein E genotype with duration of time to achieve a stable warfarin dose in African-American patients.

Study Objective: To test the hypothesis that genotypes for proteins affecting vitamin K availability influence the duration of time required to achieve a stable warfarin dose in African-American patients.

Design: Retrospective cohort study.

Setting: Pharmacist-managed antithrombosis clinic.

Effect of repeated screw joint closing and opening cycles on implant prosthetic screw reverse torque and implant and screw thread morphology.

Statement Of Problem: Clinicians must know if a new screw can predictably increase reverse torque after multiple screw insertion cycles.

Purpose: The purpose of this study was (1) to compare the effect of multiple implant prosthetic screw insertion and removal cycles on reverse torque, (2) to determine whether a new screw, after multiple screw insertion cycles, affects reverse torque, and (3) to assess implant and prosthetic screw thread surface morphology with scanning electron microscopy (SEM).

Material And Methods: One primary screw was paired with an implant (MT Osseospeed) and inserted to 25 Ncm torque 9, 19, 29, or 39 times (n=10).

Pharmacogenomics of warfarin dose requirements in Hispanics.

While Hispanics are the largest and most rapidly growing minority population in the United States, they are underrepresented in pharmacogenomic studies with warfarin. We sought to determine the combination of clinical and genetic influences of warfarin dose requirements in Hispanics. In addition, we tested the performance of published warfarin dosing algorithms derived from largely non-Hispanic cohorts in an inner-city U.

Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.

Study Objective: To identify patient-specific factors associated with spironolactone-induced potassium level elevation in patients with heart failure.

Design: Prospective cohort study.

Setting: Two adult heart failure clinics.

Influence of cyclooxygenase-1 genotype on ex vivo aspirin response in patients at risk for stroke.

Background: We sought to determine whether cyclooxygenase-1 (PTGS1) genotype is associated with the ability of aspirin to inhibit platelet aggregation in patients at risk for stroke.

Methods: Blood and urine samples were collected from 60 subjects, including 28 African Americans, who were taking aspirin for primary or secondary stroke prevention. Samples were analyzed for the PTGS1 A-707G, PTGS1 P17L, and glycoprotein IIIa (ITGB3)P1(A1/A2) genotypes, ex-vivo platelet aggregation, serum cholesterol, plasma salicylate levels, and urinary 11-dehydrothromboxane B(2) (11-dhTxB(2)) concentrations.

Objective measurement of periocular pigmentation.

Purpose: To evaluate the Minolta CR-400 chromameter in objectively measuring periocular/facial pigmentation in subjects of different ethnicities.

Methods: The CR-400 was used to obtain skin color measurements from 75 African-American, Caucasian and Hispanic subjects in 16 facial and periocular locations. Comparisons between ethnic and Fitzpatrick groups and instrument reliability were analyzed.

Factors influencing warfarin dose requirements in African-Americans.

Introduction: African-Americans are under-represented in studies assessing contributors to warfarin response. Our primary objective was to determine whether the genes for cytochrome P450 (CYP) 2C9, nicotinamide adenine dinucleotide phosphate, reduced, quinone oxidoreductase (NQO1) and vitamin K epoxide reductase complex subunit 1 (VKORC1) are associated with warfarin dose requirements in African-Americans.

Patients And Methods: The following factors were assessed: demographics; clinical data; the CYP2C9 Arg144Cys (*2), Ile358Leu (*3) and Asp360Glu (*5); NQO1 Pro187Ser (*1/*2); and VKORC1 G6853C genotypes were analyzed in 115 African-Americans on stable warfarin doses.

Association of beta-blocker dose with serum procollagen concentrations and cardiac response to spironolactone in patients with heart failure.

Study Objective: To determine whether beta-blocker dose influences cardiac collagen turnover and the effects of spironolactone on cardiac collagen turnover in patients with heart failure.

Design: Prospective clinical study.

Setting: Two heart failure centers.

Racial differences in potassium response to spironolactone in heart failure.

Evidence of racial differences in aldosterone concentrations and K+ disposition suggests that response to aldosterone antagonism might vary by race. The authors sought to determine whether K+ response to spironolactone differs between African Americans and Caucasians with heart failure. Heart failure patients of African-American (n = 34) or Caucasian (n = 17) race were started on spironolactone 12.

Embolization of intracranial aneurysms with hydrogel-coated coils versus inert platinum coils: effects on packing density, coil length and quantity, procedure performance, cost, length of hospital stay, and durability of therapy.

Background And Purpose: The durability of aneurysm coil embolization is thought to depend on packing density. The expansile property of hydrogel coating on coils increases volumetric packing per coil length. We describe our experience using hydrogel-coated coils (HydroCoils) compared with inert platinum coils in intracranial aneurysm embolization.

Sex difference in the antiplatelet effect of aspirin in patients with stroke.

Background: There is substantial interpatient variability in response to aspirin after an ischemic stroke or transient ischemic attack (TIA), as assessed by ex vivo effects of aspirin on platelet aggregation. The factors contributing to this variability are not well defined.

Objective: To determine whether demographic, social, or clinical characteristics are associated with ex vivo response to aspirin in patients with a history of stroke or TIA.

Racial differences in patients' potassium concentrations during spironolactone therapy for heart failure.

Study Objective: To determine whether the effects of spironolactone on potassium homeostasis vary by race by comparing serum potassium concentrations and potassium supplement use in African-American and Caucasian patients receiving spironolactone for heart failure.

Design: Retrospective medical record review.

Setting: Two heart failure centers.

Orthodontics and temporomandibular disorder: a meta-analysis.

As the importance of evidence-based health care has grown, meta-analysis has become more widely used in the medical and dental fields. In this meta-analysis, the relationship between traditional orthodontic treatment, including the specific type of appliance used and whether extractions were performed, and the prevalence of temporomandibular disorders (TMD) was investigated. After an exhaustive literature search of 960 articles, we found 31 that met the inclusion criteria (18 cross-sectional studies or surveys and 13 longitudinal studies).

Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce.

Several epidemiological studies suggest a lower incidence of prostate cancer in men who routinely consume tomato products. Tomatoes are the primary dietary source of lycopene, which is among the most potent antioxidants of the carotenoids. Men with clinical stage T1 or T2 prostate adenocarcinoma were recruited (n = 32) and consumed tomato sauce based pasta dishes for 3 weeks (equivalent to 30 mg of lycopene per day) before radical prostectomy.