Publications by authors named "Marloes M G van der Leest"
Background Multiparametric MRI (mpMRI) is effective for detecting prostate cancer (PCa); however, there is a high rate of equivocal Prostate Imaging Reporting and Data System (PI-RADS) 3 lesions and false-positive findings. Purpose To investigate whether fluorine 18 (F) prostate-specific membrane antigen (PSMA) 1007 PET/CT after mpMRI can help detect localized clinically significant PCa (csPCa), particularly for equivocal PI-RADS 3 lesions. Materials and Methods This prospective study included participants with elevated prostate-specific antigen (PSA) levels referred for prostate mpMRI between September 2020 and February 2022.
View Article and Find Full Text PDFUnlabelled: The 2021 European Association of Urology recommendations for early prostate cancer detection included a risk-based algorithm. Risk assessment methods are proposed to prevent excessive use of prostate magnetic resonance imaging (MRI) and biopsy, simultaneously reducing overdiagnosis and overtreatment. However, the clinical implications of sequential use of risk assessment tests have not yet been properly assessed.
View Article and Find Full Text PDFArticle Synopsis
- This study looked at ways to tell if men might have serious prostate cancer without doing too many tests, which can be uncomfortable and not always necessary.
- Researchers tested a method called SelectMDx along with another test, mpMRI, to see how they worked together to help figure out who really needed a biopsy.
- They found that using SelectMDx helped avoid a lot of unnecessary biopsies, but sometimes it missed detecting some high-grade cancers, so they are still figuring out the best way to use these tests together.
Article Synopsis
- A study aimed to define a baseline for pelvic lymph nodes using advanced 7 Tesla MRI to improve validation and assessment of lymph node dissections in pelvic cancers.
- The research involved imaging 11 healthy volunteers, resulting in the detection of 564 lymph nodes, with an average of 51.3 nodes per person and a significant portion being small (≤2 mm in diameter).
- Findings indicate substantial variation in the number of visible lymph nodes among individuals, but a consistent size distribution, suggesting that the many small nodes pose challenges for effective surgical removal and detection of metastases.
Background: Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non-invasive techniques for the detection of clinically significant disease, leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the association between a novel urinary biomarker-based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection.
Methods: This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies.
Objectives: To determine transrectal ultrasound (TRUS) visibility of magnetic resonance (MR) lesions.
Methods: Data from 34 patients with 56 MR lesions and prostatectomy were used. Five observers localized and determined TRUS visibility during retrospective fusion.