Publications by authors named "Marlies Otto"
Reprod Toxicol
September 2005
Article Synopsis
- The study assessed how a tiered morphological approach can detect developmental neurotoxicity in rat offspring treated with methylazoxymethanol (MAM) during pregnancy.
- The approach involved measuring various morphometric parameters and showed significant effects at different levels, from overall brain size to specific neuron loss in the hippocampus, while cerebellar neurons remained unaffected.
- The results demonstrated that as researchers progressed through the tiers (from basic size measurements to detailed neuron evaluation), they could better identify the extent and specific locations of brain damage.
