Introduction: infections caused by protozoa of the genus Leishmania are a global health problem with a high prevalence in underdeveloped countries. There is no vaccine against this disease at present and the treatment used is poor, so the search for more effective and safe medicines is an urgent need.
Objective: to assess the in vitro antileishmanial activity of six aqueous and hydroalcohol extracts from marine organisms.
In this paper we analyzed the antiprotozoal effects of eighteen Cuban propolis extracts (brown, red and yellow type) collected in different geographic areas, using Leishmania amazonensis (as a model of intracellular protozoa) and Trichomonas vaginalis (as a model of extracellular protozoa). All evaluated propolis extracts caused inhibitory effect on intracellular amastigotes of L. amazonensis.
View Article and Find Full Text PDFIn this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.
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