Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study.

Background And Aims: In the Partial Oral Treatment of Endocarditis (POET) trial, stabilized patients with left-sided infective endocarditis (IE) were randomized to oral step-down antibiotic therapy (PO) or conventional continued intravenous antibiotic treatment (IV), showing non-inferiority after 6 months. In this study, the first guideline-driven clinical implementation of the oral step-down POET regimen was examined.

Methods: Patients with IE, caused by Staphylococcus aureus, Enterococcus faecalis, Streptococcus spp.