[Croatian Society for Haematology and Transfusion Medicine Guidelines on the diagnosis and management of heparin induced thrombocytopenia (HIT)].

Heparin induced thrombocytopenia (HIT) is a serious complication of heparin administration. In the last decade, this clinical syndrome has come into the focus of interest, primarily because of the severe thromboembolic complications that may lead to lethal outcome. In addition, great improvements have been made in the treatment with direct thrombin inhibitors and in laboratory diagnosis of HIT.

[Polymorphism of platelet glycoprotein Ibalpha as a genetic predictor of coronary artery disease].

Atherosclerosis is a multifactorial disease caused by the interaction between genetic predisposition and environmental influences. Polymorphisms within platelet membrane antigens have been recognized as a potential risk factor involved in pathogenesis of coronary artery disease (CAD). Results of different studies on association of platelet membrane polymorphisms and CAD are controversial.