Publications by authors named "Marleena Repo"
Article Synopsis
- Gastrointestinal endoscopy is widely used in children with abdominal issues, and while atrophic duodenal changes are often linked to celiac disease, the implications of non-atrophic duodenal changes are less understood.
- In a study of 1,170 children, 4.4% had non-atrophic changes; common findings included non-specific inflammation and intraepithelial lymphocytosis, with affected patients showing higher instances of blood in stools, anemia, and positive celiac serology compared to those with normal findings.
- During long-term follow-up, some patients with initial non-atrophic changes developed celiac disease, indicating the need for ongoing monitoring even when formal diagnoses are not established at
Article Synopsis
- Low ferritin levels are commonly observed in patients with screen-detected coeliac disease, with 21% showing ferritin levels under 15 μg/L and 40% under 30 μg/L at diagnosis, despite being non-anaemic.
- After 1-2 years on a gluten-free diet (GFD), ferritin levels improved significantly from a median of 41.5 μg/L to 86.0 μg/L, yet 21% of patients still had ferritin levels under 30 μg/L.
- Interestingly, low ferritin levels didn't correlate with the severity of symptoms, quality of life, or other health indicators, suggesting that even though low ferritin is common in these patients
Article Synopsis
- * Out of 239 adult patients, 180 followed a strict gluten-free diet, but 18% reported ongoing symptoms, primarily gastrointestinal issues, along with fatigue and joint pain.
- * Patients with persistent symptoms had greater health concerns and a lower quality of life compared to those without symptoms, and none of the childhood diagnosis features predicted symptom persistence in adulthood.
Purpose: We evaluated adherence to a gluten-free diet and associated factors in adult celiac disease patients diagnosed in childhood.
Methods: Comprehensive medical data on 955 pediatric celiac disease patients was collected and study questionnaires sent to 559 who were now adults. All variables were compared between strictly adherent and non-adherent patients.
Objective: Assessment of the upper gastrointestinal tract (UGI) may enable more personalized treatment strategies in pediatric inflammatory bowel disease (IBD). However, data on the frequency and significance of these findings remain limited.
Methods: Data on 132 pediatric IBD patients with systematic UGI sampling were collected and the baseline characteristics and presence of complications compared between those with and without histological UGI findings.
Objectives: The clinical significance of Helicobacter pylori-negative chronic gastritis (HPNCG) in children is unclear. We examined this issue in patients who had undergone esophagogastroduodenoscopy with systematic gastric sampling.
Methods: Data of 1178 consecutive children who underwent diagnostic esophagogastroduodenoscopy were collected.
Background: Undelayed diagnosis is thought to be a major determinant for good prognosis in pediatric inflammatory bowel disease (PIBD). However, factors predicting diagnostic delay and the consequences of this remain poorly defined. We investigated these issues in a well-defined cohort of PIBD patients.
View Article and Find Full Text PDFAnemia is a frequent finding in children with celiac disease but the detailed pathophysiological mechanisms in the intestine remain obscure. One possible explanation could be an abnormal expression of duodenal iron transport proteins. However, the results have so far been inconsistent.
View Article and Find Full Text PDFNon-biopsy diagnosis of celiac disease is possible in children with anti-transglutaminase 2 antibodies (TGA) > 10× the upper limit of normal (ULN) and positive anti-endomysial antibodies (EMA). Similar criteria have been suggested for adults, but evidence with different TGA assays is scarce. We compared the performance of four TGA tests in the diagnosis of celiac disease in cohorts with diverse pre-test probabilities.
View Article and Find Full Text PDFVariable endoscopic and histological findings of esophageal lining are often detected in celiac disease, with unknown significance. We investigated the frequency and significance of such abnormalities in children. Macroscopic esophageal findings as reported by endoscopist and histological results by pathologist were compared between 316 celiac disease patients and 378 disease controls who had undergone upper gastrointestinal endoscopy with systematic esophageal biopsy sampling.
View Article and Find Full Text PDFSeverity of Villous Atrophy at Diagnosis in Childhood Does Not Predict Long-term Outcomes in Celiac Disease.
J Pediatr Gastroenterol Nutr
July 2020
Article Synopsis
- The study aimed to investigate if the severity of villous atrophy in children diagnosed with celiac disease affects their clinical characteristics and long-term health outcomes.
- It analyzed data from 906 children and assessed long-term outcomes in 503 adults using questionnaires, finding that 34% had partial, 40% subtotal, and 26% total villous atrophy.
- While children with milder lesions tended to have better health indicators, the study concluded that severe villous atrophy at diagnosis doesn't predict long-term complications or quality of life in adulthood.
Background And Aims: Intestinal diseases are regarded as a common cause of anemia, but the diagnostic outcomes of children with anemia undergoing endoscopic investigations are unclear. We investigated this issue in a large cohort of children.
Methods: Indications for and findings of consecutive gastrointestinal (GI) endoscopies were collected.
Article Synopsis
- Celiac disease is usually diagnosed through autoantibody tests, but this can miss seronegative cases, especially in children with duodenal lesions.
- A study analyzed 1172 Finnish and 264 Romanian children to examine the prevalence of seronegative duodenal lesions and their outcomes.
- The findings showed that serious cases of pediatric seronegative celiac disease are rare, and more common causes of duodenal lesions include inflammatory bowel disease and infections, with no cases developing into celiac disease during long-term follow-up.
Anemia and Iron Deficiency in Children With Potential Celiac Disease.
J Pediatr Gastroenterol Nutr
January 2017
Objectives: Active screening for celiac disease frequently detects seropositive children with normal villous morphology (potential celiac disease). It remains unclear whether these subjects should be treated. We here investigated the prevalence of anemia and iron deficiency in children with potential and mucosal atrophy celiac disease.
View Article and Find Full Text PDFGoals: The aim of the present study was to compare clinical, serological, and histological manifestations between children with anemia and without anemia at celiac disease (CD) diagnosis.
Background: Despite being a common finding, the association between the presence of anemia and clinicohistopathological presentation of CD in children remains obscure.
Study: A total of 455 patients with CD <18 years of age were divided into those with anemia and those without anemia at diagnosis.