Publications by authors named "Marleen Kawahara"
Article Synopsis
- CYP1A enzymes are important for drug metabolism and can activate harmful compounds, influencing drug interactions and detoxification.
- Researchers created a stable cell line to test how various chemicals affect CYP1A levels through the aryl hydrocarbon receptor (AhR), identifying both inducers and inhibitors.
- Notably, omeprazole significantly increased enzyme activity, while kava and others effectively reduced the activity, demonstrating that cell-based bioassays can efficiently detect substances impacting CYP1A regulation.
Exposure to certain xenochemicals can alter the catalytic activity of the major drug-metabolizing enzyme, CYP3A4, either by enhancing expression of this cytochrome P450 or inhibiting its activity. Such alterations can result in adverse consequences stemming from drug-drug interactions. A simplified and reliable tool for detecting the ability of candidate drugs to alter CYP3A4 levels or inhibit catalytic activity was developed by stable integration of human pregnane X receptor and a luciferase vector harboring the CYP3A4 enhancers.
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