Publications by authors named "Marleen J Emaus"
Background: Coronary artery calcifications (CAC) is a strong predictor of cardiovascular disease (CVD), which can be automatically quantified on routine breast radiotherapy planning computed tomography (CT) scans. Around 8% of patients have (very) high CAC scores and corresponding increased risks of CVD.
Aim: This study explores whether, how, and under what conditions women with breast cancer want to be informed about their CAC-based CVD risk.
Background: Extremely dense breast tissue is associated with increased breast cancer risk and limited sensitivity of mammography. The DENSE trial showed that additional magnetic resonance imaging (MRI) screening in women with extremely dense breasts resulted in a substantial reduction in interval cancers. The cost-effectiveness of MRI screening for these women is unknown.
View Article and Find Full Text PDFImportance: Cardiovascular disease (CVD) is common in patients treated for breast cancer, especially in patients treated with systemic treatment and radiotherapy and in those with preexisting CVD risk factors. Coronary artery calcium (CAC), a strong independent CVD risk factor, can be automatically quantified on radiotherapy planning computed tomography (CT) scans and may help identify patients at increased CVD risk.
Objective: To evaluate the association of CAC with CVD and coronary artery disease (CAD) in patients with breast cancer.
Background In the first (prevalent) supplemental MRI screening round of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial, a considerable number of breast cancers were found at the cost of an increased false-positive rate (FPR). In incident screening rounds, a lower cancer detection rate (CDR) is expected due to a smaller pool of prevalent cancers, and a reduced FPR, due to the availability of prior MRI examinations. Purpose To investigate screening performance indicators of the second round (incidence round) of the DENSE trial.
View Article and Find Full Text PDFArticle Synopsis
- A study in the Netherlands involved over 40,000 women aged 50-75 with extremely dense breast tissue, comparing those who received supplemental MRI screenings to those who had only mammograms.
- MRI screenings significantly reduced the rate of interval breast cancers, showing a 2.5 per 1000 screenings improvement in early detection compared to mammography alone.
- Although 59% of participants accepted the invitation for MRI, the screening process had a relatively low positive predictive value, with a small percentage experiencing adverse events.
Introduction: Cardiovascular disease (CVD) is an important cause of death in breast cancer survivors. Some breast cancer treatments including anthracyclines, trastuzumab and radiotherapy can increase the risk of CVD, especially for patients with pre-existing CVD risk factors. Early identification of patients at increased CVD risk may allow switching to less cardiotoxic treatments, active surveillance or treatment of CVD risk factors.
View Article and Find Full Text PDFPurpose: This study automatically quantified calcifications in coronary arteries (CAC) and thoracic aorta (TAC) on breast planning computed tomography (CT) scans and assessed its reproducibility compared to manual scoring.
Material And Methods: Dutch (n = 1199) and Singaporean (n = 1090) breast cancer patients with radiotherapy planning CT scan were included. CAC and TAC were automatically scored using deep learning algorithm.
Background: Organ-sparing approaches, including wait-and-see and local excision, are increasingly being offered to patients with rectal cancer following a good response to neoadjuvant therapy. Preferences regarding these treatment strategies are yet unknown.
Objective: This study aimed to determine the preferences and utility scores for rectal cancer treatment approaches.
Background: Noninvasive or minimally invasive treatments are being developed as alternatives to surgery for patients with early-stage breast cancer. Patients' preferences with regard to these new treatments have not been investigated.
Objectives: To assess preferences of patients with breast cancer and of healthy women regarding these new techniques, compared with conventional surgical treatments.
Background: The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor-negative breast cancer risk.
Objective: This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor-defined breast cancer risk.
Design: A total of 335,054 female participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were included in this study (mean ± SD age: 50.
Objectives: Differences in breast density between populations may explain part of the variation in regional breast cancer screening performance. This study aimed to determine whether regional differences in breast density distribution are present in the Dutch screening population.
Methods: As part of the DENSE trial, mammographic density was measured using a fully-automated volumetric method.
Article Synopsis
- Women with extremely dense breasts face a higher risk of breast cancer and have lower mammogram detection rates; thus, they typically receive only mammography screenings.
- The DENSE trial is exploring the effectiveness of adding MR imaging alongside mammography to improve early breast cancer detection for women aged 50-75 with extremely dense breasts.
- This randomized controlled trial compares results between those receiving just mammography to those receiving both mammography and MR imaging, aiming to assess if MR imaging reduces interval cancers and justifies its added costs.
It has been observed that women living in urban areas have a higher mammographic density (MD) compared to women living in rural areas. This association might be explained by regional differences in reproductive and lifestyle factors or perhaps by variation in exposure to ambient air pollution as air pollution particles have been described to show estrogenic activity. We investigated the association between degree of urbanization and MD, and aimed to unravel the underlying etiology.
View Article and Find Full Text PDFLong-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer.
View Article and Find Full Text PDFBackground: A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change.
Objective: We investigated the relation between BMI and weight change and subsequent colon and rectal cancer risk.