Publications by authors named "Marleen H M de Moor"

Mood variability, the day-to-day fluctuation in mood, differs between individuals and develops during adolescence. Because adolescents show higher mood variability and average mood than children and adults, puberty might be a potential biological mechanism underlying this increase. The goal of this preregistered developmental study was to examine the neural and hormonal underpinnings of adolescent-specific within-person changes in mood variability, with a specific focus on testosterone, cortisol, pubertal status, and resting-state functional brain connectivity.

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Fathers are of great importance for healthy child development. This randomized controlled study investigated the longer-term effects of an intervention using a soft baby carrier on fathers' observed sensitive caregiving, involvement, and oxytocin and cortisol levels. First-time fathers were randomly assigned to use a baby carrier ( = 41) or baby seat ( = 39) and were asked to use the carrier or seat for at least 6 h per week for 3 weeks.

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Article Synopsis
  • The study examined how parenting practices and adolescent emotions influence each other, focusing on whether these interactions vary across different family types.
  • Using a method called Subgrouping Group Iterative Multiple Model Estimation (S-GIMME), the researchers analyzed daily data from 129 adolescents over 100 days to explore these relationships.
  • The results revealed that instead of finding common patterns among families, each family's dynamics were unique, indicating that the link between parenting styles and adolescent feelings is specific to each family.
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  • The study examines how parenting stress and child behavior problems (both internalizing and externalizing) are interconnected over time, specifically from the ages of 9 months to 9 years.
  • Data was collected from over 7,200 caregiver-child pairs in Ireland and analyzed using advanced statistical models to explore these relationships.
  • Findings revealed bidirectional influences between parenting stress and child behavior issues from ages 5 to 9, but parental warmth or hostility did not mediate these relationships.
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This randomized, double-blind, placebo-controlled within-subject study examined the effects of intranasal administration of oxytocin and vasopressin on fathers' sensitive and challenging parenting behaviors. Furthermore, we examined the moderating role of fathers' early childhood experiences. The sample consisted of 70 fathers with their 2- to 12-month-old infants.

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In a randomized double-blind within-subject control study we investigated the effects of oxytocin and vasopressin administration on neural reactivity to infant cry sounds in 70 first-time fathers in the first year of fatherhood. Additionally, we examined whether effects of oxytocin and vasopressin administration on neural reactivity were moderated by fathers' early childhood experiences. Neural reactivity to infant cry sounds (versus control sounds) was measured using functional magnetic resonance imaging (fMRI).

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This longitudinal study examined developmental trajectories of infant sleep problems from 3 to 24 months old and investigated associations with infant-parent attachment security and dependency. In a sample of 107 Israeli families, number and duration of infant nighttime awakenings were measured at 3, 6, 9, and 24 months old, using mothers' and fathers' reports on the Brief Infant Sleep Questionnaire (BISQ). Infant-parent attachment security and infant-parent dependency was assessed at 24 months old, using the observer Attachment Q-Sort procedure (AQS) with both parents.

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Background: Young people with disabilities are more at risk of experiencing loneliness in later life than their typically developing peers.

Aim: To identify those who become lonely in later life, trajectories of perceived parent and peer support from adolescence to adulthood of young people with a visual impairment were studied.

Methods: A total of 316 adolescents (M = 18 years; SD = 6.

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Article Synopsis
  • The study focuses on how oxytocin and vasopressin affect first-time fathers' parenting behaviors and their responses to their infants, particularly in relation to infant cries and perceived threats.
  • The research involves 55 participants who will self-administer either hormone treatments or a placebo over three sessions, with observations made on their interactions and responses during playtime, alongside neural imaging assessments.
  • The findings aim to shed light on the connection between hormones, childhood experiences, and paternal behaviors, which could have implications for understanding early fatherhood.
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  • The study explores how both genetic and environmental factors, particularly maternal influences, contribute to problem behavior in children.
  • The research involved 1,154 children, analyzing polygenic risk scores from genome-wide studies on psychiatric disorders to assess their link to maternal risks and behavioral issues.
  • Findings suggest a correlation between genetic predispositions (especially related to schizophrenia) and early environmental risks, indicating that both factors may interact to increase the likelihood of problem behaviors in children.
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  • Adverse childhood experiences (ACEs) negatively impact women's ability to adapt to parenthood, but how this happens is not fully understood.
  • A study of 193 first-time mothers examined how their autonomic nervous system responses (like heart rate changes) during a baby cry test related to their ACEs and later parenting outcomes.
  • The findings suggest that high ACEs are linked to lower parasympathetic reactivity, which could lead to increased depressive symptoms post-birth, highlighting the role of childhood trauma in shaping emotional responses to parenting.
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Executive Functions (EFs) have been associated with aggression in children and adolescents. EFs as higher-order cognitive abilities are assumed to affect cognitive functions such as Social Information Processing (SIP). We explored SIP skills as a mediating mechanism linking EFs to aggression in adolescents with mild to borderline intellectual disability (MBID with IQ from 50-84), a high risk group for aggressive behaviors and EF impairments.

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  • Physical activity (PA) can influence genetic factors linked to obesity, leading to a deeper understanding of how genetics and lifestyle interact in shaping body fat.
  • A study involving over 200,000 adults analyzed the relationship between PA and various obesity-related measurements, confirming that the impact of the FTO gene is reduced in physically active individuals.
  • The research also discovered 11 new genetic regions associated with body fat, indicating that considering lifestyle factors like PA can help uncover more genetic links to obesity.
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This study tested experimentally whether the combination of a history of childhood abuse and confrontation with difficult infant temperament is associated with negative changes in parenting self-efficacy. First-time pregnant women (N = 243) participated in the Adult Attachment Interview, which was used to assess the occurrence of abuse by parents in childhood and unresolved representations, and completed a task asking them to respond to infant cries. Sixty of the 243 participants (25%) experienced childhood abuse, mostly physical or sexual.

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Anger is an emotion consisting of feelings of variable intensity ranging from mild irritation to intense fury. High levels of trait anger are associated with a range of psychiatric, interpersonal, and health problems. The objectives of this study were to explore heterogeneity of anger as measured by the Spielberger Trait Anger Scale (STAS), and to assess the association of the different anger facets with a selection of psychiatric disorders covering externalizing and internalizing problems, personality disorders, and substance use.

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Alcohol dependence (AD) is among the most common and costly public health problems contributing to morbidity and mortality throughout the world. In this study, we investigate the genetic basis of AD in a Dutch population using data from the Netherlands Twin Register (NTR) and the Netherlands Study of Depression and Anxiety (NESDA). The presence of AD was ascertained via the Alcohol Use Disorders Identification Test (AUDIT) applying cut-offs with good specificity and sensitivity in identifying those at risk for AD.

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Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts.

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Importance: Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63,000 participants (including MDD cases).

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  • Variation in liver enzyme levels is moderately heritable, with twin-family studies showing a heritability estimate around 16% for gamma-glutamyl transferase (GGT) and 11% for aspartate aminotransferase (AST), while alanine aminotransferase (ALT) showed a lower estimate of 6%.
  • Genome-wide association studies have only identified less than 2% of the genetic variance linked to significant single-nucleotide polymorphisms (SNPs), leaving much of the genetic variation in liver enzymes undetected.
  • The study compared two SNP-based heritability estimation methods using data from 5,421 Dutch individuals and highlighted that while genome-wide SNP data offers valuable insights, there is still a
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  • Mega-analytic studies in behavior genetics often face challenges in harmonizing different measures of personality traits, necessary for effective analysis.
  • This research, conducted by the Genetics of Personality Consortium, utilized Item-Response Theory (IRT) to align data from over 160,000 individuals across 23 cohorts assessing Neuroticism and Extraversion through nine different inventories.
  • The findings revealed that IRT successfully standardized measurements, confirmed heritability of these traits, and suggested that genetic influences show differences based on sex, highlighting the method's potential for enhancing statistical power in similar studies.
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Objective: The current study aimed to describe what proportion of variation in adult alcohol intake is attributable to genetic differences among individuals and what proportion to differences in environmental experiences individuals have been exposed to. Effects of age, gender, spousal resemblance, and cultural transmission of alcohol intake from parents to offspring were taken into account.

Method: In a twin-family design, the effects of genetic and cultural transmission and shared and nonshared environment on alcohol intake were estimated with genetic structural equation models.

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Background: Blood levels of gamma-glutamyl transferase (GGT) are used as a marker for (heavy) alcohol use. The role of GGT in the anti-oxidant defense mechanism that is part of normal metabolism supposes a causal effect of alcohol intake on GGT. However, there is variability in the response of GGT to alcohol use, which may result from genetic differences between individuals.

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Social cognitive models of health behavior propose that individual differences in leisure time exercise behavior are influenced by the attitudes towards exercise. At the same time, large scale twin-family studies show a significant influence of genetic factors on regular exercise behavior. This twin-sibling study aimed to unite these findings by demonstrating that exercise attitudes can be heritable themselves.

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