Opioid-related respiratory and gastrointestinal adverse events in patients with acute postoperative pain: prevalence, predictors, and burden.

Opioid-induced respiratory depression (OIRD) and postoperative nausea and vomiting (PONV) are challenging, resource-intensive, and costly opioid-related adverse events (ORAEs). Utilizing the Premier Healthcare Database, we identified patients > 18 years old, who underwent at least one surgical procedure of interest (i.e.

The effectiveness of a multicenter quality improvement collaborative in reducing inpatient mortality.

Motivation And Background: This study examines the evidence that a particular quality improvement collaborative that focused on Quality, Efficiency, Safety and Transparency (QUEST) was able to improve hospital performance.

Setting: The collaborative included a range of improvement vehicles, such as sharing customized comparative reports, conducting online best practices forums, using 90-day rapid-cycle initiatives to test specific interventions, and conducting face-to-face meetings and quarterly one-on-one coaching sessions to elucidate opportunities.

Methods: With these kinds of activities in mind, the objective was to test for the presence of an overall "QUEST effect" via statistical analysis of mortality results that spanned 6 years (2006-2011) for more than 600 acute care hospitals from the Premier alliance.