Publications by authors named "Marla Kay S Sommerfield"
Article Synopsis
- The study explores the use of circulating tumor DNA (ctDNA) as a non-invasive method to monitor endometrial cancer, aiming to identify unique tumor-specific DNA junctions that could indicate tumor burden and prognosis.
- Whole-genome Mate-Pair sequencing was conducted on 11 patients with advanced endometrial cancer to find chromosomal rearrangements, and ctDNA levels were measured in pre- and post-surgery plasma samples using quantitative PCR.
- Results showed ctDNA was present in 60% of samples before surgery and 27% after, with pre-surgical detection correlating with aggressive disease indicators, suggesting potential for ctDNA as a biomarker, but further research is needed for validation.
