Identification of Particles in Parenteral Drug Raw Materials.

The presence of particles in drug products is regulated. These particles may be present before the beginning of the manufacturing process-that is, from the raw materials. To prevent the inclusion of these particles, it is important to understand their composition and origin, so that raw material quality, processing, and shipping can be improved.

Raman, Infrared, and Laser-Induced Breakdown Spectroscopy Identification of Particles in Raw Materials.

Raw materials need to be of a certain quality with respect to physical and chemical composition. They also need to have no contaminants, including particles, because these could indicate raw material impurities or contaminate the product. Particle identification allows determination of process conditions that caused them and whether the quality of the final product is acceptable.

Identification of Particles in Raw Materials.

Raw materials need to be of a certain quality with respect to physical and chemical composition. They also need to have no contaminants in the form of particles because these could get into the product or indicate the raw materials are not pure enough to make a good quality product. When particles are found, it is important to identify their chemical and elemental composition to correct any process errors that can cause them and to have acceptable quality of the final product.

On-line monitoring and identification of bioaerosols.

Fast analysis of bioaerosols in clean room environments is necessary in order to prevent contamination of pharmaceutical products, minimize machine downtimes, or both. The detection and identification of microbes will be carried out in several steps: After impaction of the aerosol on a surface, the particles are presorted with glancing light illumination and fluorescence imaging in order to distinguish between abiotic and biotic particles. Since only the biotic particles are of interest, the analysis time can be minimized due to reduction of the data set.

Asbestos mineral analysis by UV Raman and energy-dispersive X-ray spectroscopy.

The applicability of a UV micro-Raman setup was assessed for the rapid identification of fibrous asbestos minerals using 257 and 244 nm laser light for excitation. Raman spectra were obtained from six asbestos reference standards belonging to two basic structural groups: the serpentines (chrysotile) and the amphiboles (crocidolite, tremolite, amosite, anthophyllite, and actinolite). The UV Raman spectra reported here for the first time are free from fluorescence, which is especially helpful in assessing the hydroxyl-stretching vibrations.

Chemotaxonomic identification of single bacteria by micro-Raman spectroscopy: application to clean-room-relevant biological contaminations.

Microorganisms, such as bacteria, which might be present as contamination inside an industrial food or pharmaceutical clean room process need to be identified on short time scales in order to minimize possible health hazards as well as production downtimes causing financial deficits. Here we describe the first results of single-particle micro-Raman measurements in combination with a classification method, the so-called support vector machine technique, allowing for a fast, reliable, and nondestructive online identification method for single bacteria.