Trajectories of school absences across compulsory schooling and their impact on children's academic achievement: An analysis based on linked longitudinal survey and school administrative data.

Prior research has identified that school absences harm children's academic achievement. However, this literature is focused on brief periods or single school years and does not consistently account for the dynamic nature of absences across multiple school years. This study examined dynamic trajectories of children's authorised and unauthorised absences throughout their compulsory school career in England.

Choice of reaction progress variable under preferential diffusion effects in turbulent syngas combustion based on detailed chemistry direct numerical simulations.

The combustion of hydrogen and carbon-monoxide mixtures, so-called syngas, plays an increasingly important role in the safety context of non-fossil energy generation, more specifically in the risk management of incidents in process engineering plants for ammonia synthesis and in nuclear power plants. In order to characterize and simulate syngas/air combustion on industrially relevant scales, subgrid modelling is required, which is often based on a reaction progress variable. To understand the influence of different fuel compositions, turbulence intensities and flame topologies on different possible definitions of reaction progress variable, detailed chemistry direct numerical simulations data of premixed, lean hydrogen/air and syngas/air flames has been considered.

Mutual interference between memory encoding and motor skills: the influence of motor expertise.

In cognitive-motor dual-task situations, the extent of performance decrements is influenced by the attentional requirements of each task. Well-learned motor skills should be automatized, leading to less interference. This study presents two studies combining an episodic memory encoding task with well-practiced motor tasks in athletes.

Direct numerical simulation of an unsteady wall-bounded turbulent flow configuration for the assessment of large-eddy simulation models.

A new benchmark case for the evaluation of direct numerical simulation (DNS) and large-eddy simulation (LES) models and methods is presented in this study. The known Taylor-Green vortex is modified by replacing the periodic boundary conditions in one direction with a no-slip boundary. A passive scalar is added and transported from the wall into the fluid.

Surface topologies and self interactions in reactive and nonreactive Richtmyer-Meshkov instability.

The reactive Richtmyer-Meshkov instability (RMI) exhibits strong wrinkling of a reactive flame front after an interaction with a shock wave. High levels of deformation and wrinkling can cause the flame surface to intersect with itself, leading to the events of flame self interactions (FSI). As FSI can have a significant influence on the development and topology of the flame surface, it should be considered an important factor affecting the burning characteristics of the flame.

Entropy Generation during Head-On Interaction of Premixed Flames with Inert Walls within Turbulent Boundary Layers.

The statistical behaviours of different entropy generation mechanisms in the head-on interaction of turbulent premixed flames with a chemically inert wall within turbulent boundary layers have been analysed using Direct Numerical Simulation data. The entropy generation characteristics in the case of head-on premixed flame interaction with an isothermal wall is compared to that for an adiabatic wall. It has been found that entropy generation due to chemical reaction, thermal diffusion and molecular mixing remain comparable when the flame is away from the wall for both wall boundary conditions.

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i).

Proteasomes are broadly expressed key components of the ubiquitin-dependent protein degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is a subunit of the immunoproteasome, an inducible isoform that is predominantly expressed in hematopoietic cells. Clinically effective pan-proteasome inhibitors for the treatment of multiple myeloma (MM) nonselectively target LMP7 and other subunits of the constitutive proteasome and immunoproteasome with comparable potency, which can limit the therapeutic applicability of these drugs.

M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models.

Large multifunctional peptidase 7 (LMP7/β5i/PSMB8) is a proteolytic subunit of the immunoproteasome, which is predominantly expressed in normal and malignant hematolymphoid cells, including multiple myeloma, and contributes to the degradation of ubiquitinated proteins. Described herein for the first time is the preclinical profile of M3258; an orally bioavailable, potent, reversible and highly selective LMP7 inhibitor. M3258 demonstrated strong antitumor efficacy in multiple myeloma xenograft models, including a novel model of the human bone niche of multiple myeloma.

Near wall Prandtl number effects on velocity gradient invariants and flow topologies in turbulent Rayleigh-Bénard convection.

The statistical behaviours of the invariants of the velocity gradient tensor and flow topologies for Rayleigh-Bénard convection of Newtonian fluids in cubic enclosures have been analysed using Direct Numerical Simulations (DNS) for a range of different values of Rayleigh (i.e. [Formula: see text]) and Prandtl (i.

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Accurate ranking of compounds with regards to their binding affinity to a protein using computational methods is of great interest to pharmaceutical research. Physics-based free energy calculations are regarded as the most rigorous way to estimate binding affinity. In recent years, many retrospective studies carried out both in academia and industry have demonstrated its potential.

Parental education, television exposure, and children's early cognitive, language and behavioral development.

The association between television exposure and children's development is subject to controversial debates. Heavy television exposure may be detrimental to children by overstimulating their developing brains. It may also infringe on time that children would otherwise spend on more developmentally beneficial activities or parental interactions.

Social origin, field of study and graduates' career progression: does social inequality vary across fields?

Research on stratification and mobility has consistently shown that in the UK there is a direct impact of social origin on occupational destination net of educational attainment even for degree-holders. However, only a few studies applied a longitudinal and dynamic perspective on how intergenerational mobility shapes graduates' working careers. Using multilevel growth curve modelling and data from the 1970 British cohort study (BCS70), we contribute to this research by looking at the emergence of social inequalities during the first ten years since labour market entry.

On the stress-strain alignment in premixed turbulent flames.

The interaction of large and small scale structures is fundamental to the energy cascade in turbulent flows. The correct representation of this interaction becomes important in the context of large eddy simulation (LES), where the response of small-scale structures to the resolved quantities, or large-scale structures, must be parametrised. This challenging task becomes more demanding when LES of premixed flames are considered, as heat release affects the interaction of turbulence and chemistry occurring at the unresolved scales.

Direct Numerical Simulation of Head-On Quenching of Statistically Planar Turbulent Premixed Methane-Air Flames Using a Detailed Chemical Mechanism.

A three-dimensional compressible Direct Numerical Simulation (DNS) analysis has been carried out for head-on quenching of a statistically planar stoichiometric methane-air flame by an isothermal inert wall. A multi-step chemical mechanism for methane-air combustion is used for the purpose of detailed chemistry DNS. For head-on quenching of stoichiometric methane-air flames, the mass fractions of major reactant species such as methane and oxygen tend to vanish at the wall during flame quenching.

Enstrophy transport conditional on local flow topologies in different regimes of premixed turbulent combustion.

Enstrophy is an intrinsic feature of turbulent flows, and its transport properties are essential for the understanding of premixed flame-turbulence interaction. The interrelation between the enstrophy transport and flow topologies, which can be assigned to eight categories based on the three invariants of the velocity-gradient tensor, has been analysed here. The enstrophy transport conditional on flow topologies in turbulent premixed flames has been analysed using a Direct Numerical Simulation database representing the corrugated flamelets (CF), thin reaction zones (TRZ) and broken reaction zones (BRZ) combustion regimes.

Early Maternal Employment and Children's Vocabulary and Inductive Reasoning Ability: A Dynamic Approach.

This study investigates the relationship between early maternal employment history and children's vocabulary and inductive reasoning ability at age 5, drawing on longitudinal information on 2,200 children from the Growing Up in Scotland data. Prior research rarely addresses dynamics in maternal employment and the methodological ramifications of time-variant confounding. The present study proposes various measures to capture duration, timing, and stability of early maternal employment and uses inverse probability of treatment weighting to control for time-variant confounders that may partially mediate the effect of maternal employment on cognitive scores.

Self-Concept in Adolescents-Relationship between Sport Participation, Motor Performance and Personality Traits.

The relationship between sport participation, personality development, self-concept and self-esteem has been discussed repeatedly. In this research, a standardized written survey together with tests on motor performance were carried out with 1399 students (707 male; 692 female) in school years 7 (12.9 ± 0.

Impairing both HMA4 homeologs is required for cadmium reduction in tobacco.

In tobacco, the heavy metal P1B-ATPases HMA4.1 and HMA4.2 function in root-to-shoot zinc and cadmium transport.

Socio-economic status and motor performance of children and adolescents.

The study examines the question to what extent children and adolescents differ in terms of motor performance in dependence of their socio-economic status (SES). A sample of 1389 students in Saarland (Germany) in various grades (1st grade: age 7.26 ± 0.

The increasing unemployment gap between the low and high educated in West Germany. Structural or cyclical crowding-out?

This paper addresses trends in education-specific unemployment risks at labor market entry in West Germany from the mid-1970s to the present. In line with previous research it shows that vocationally qualified school-leavers have relatively lower unemployment risks than school-leavers with general education. Over time, the gap in unemployment risks between the low-educated and medium- and highly educated labor market entrants substantially widened for both sexes.

Structure-based optimization of non-peptidic Cathepsin D inhibitors.

We discovered a novel series of non-peptidic acylguanidine inhibitors of Cathepsin D as target for osteoarthritis. The initial HTS-hits were optimized by structure-based design using CatD X-ray structures resulting in single digit nanomolar potency in the biochemical CatD assay. However, the most potent analogues showed only micromolar activities in an ex vivo glycosaminoglycan (GAG) release assay in bovine cartilage together with low cellular permeability and suboptimal microsomal stability.

Streamline segment statistics of premixed flames with nonunity Lewis numbers.

The interaction of flame and surrounding fluid motion is of central importance in the fundamental understanding of turbulent combustion. It is demonstrated here that this interaction can be represented using streamline segment analysis, which was previously applied in nonreactive turbulence. The present work focuses on the effects of the global Lewis number (Le) on streamline segment statistics in premixed flames in the thin-reaction-zones regime.

Strength training adaptations after cold-water immersion.

Several studies analyzed the effectiveness of cold-water immersion (CWI) to support recovery after strenuous exercise, but the overall results seem to be conflicting. Most of these studies analyzed only short-term recovery effects, whereas the adaptational aspect has been widely neglected. Therefore, we analyzed the effects of repeated cooling after training sessions (CWI) on adaptations to strength training.

Motor performance and bodyweight of children and adolescents in Saarland -- status quo.

The motor performance of children and adolescents has been a subject of controversial discussion. As part of a pilot project, 839 schoolchildren from 14 different schools in Saarland were studied and their height, weight and sport motor performance were measured using the German motor performance test DMT 6-18. The results show a slight increase in the number of overweight children compared to reference samples.