MLR-predictor: a versatile and efficient computational framework for multi-label requirements classification.

Introduction: Requirements classification is an essential task for development of a successful software by incorporating all relevant aspects of users' needs. Additionally, it aids in the identification of project failure risks and facilitates to achieve project milestones in more comprehensive way. Several machine learning predictors are developed for binary or multi-class requirements classification.

Challenges and perspectives in use of artificial intelligence to support treatment recommendations in clinical oncology.

Artificial intelligence (AI) promises to be the next revolutionary step in modern society. Yet, its role in all fields of industry and science need to be determined. One very promising field is represented by AI-based decision-making tools in clinical oncology leading to more comprehensive, personalized therapy approaches.

Inefficacy of dietary test substance administration in Amphibian Metamorphosis Assay (AMA) studies.

Traditionally, the Amphibian Metamorphosis Assay (AMA; OECD TG 231) is performed by exposing Xenopus laevis tadpoles to test substances dissolved in laboratory water. Recently, the use of dietary administration has been proposed to combat poorly soluble test substances in ecotoxicologically-based regulatory endocrine disruption (ED) studies, specifically the AMA warranting an investigation into the efficacy of dietary administration. An efficacy study comprised of two phases: 1) evaluation of the physical influence of the loading process via solvent and 10, 1, and 0.

CD33(+) /HLA-DR(neg) and CD33(+) /HLA-DR(+/-) Cells: Rare Populations in the Human Decidua with Characteristics of MDSC.

Problem: Human pregnancy needs a remarkable local immune tolerance toward the conceptus. Myeloid-derived suppressor cells (MDSC) are important players promoting cancer initiation and progression by suppressing T-cell functions and thus inducing immune tolerance. Therefore, MDSC were expected within decidua.

The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8⁺ T cells.

Cytokine secretion and degranulation represent key components of CD8(+) T-cell cytotoxicity. While transcriptional blockade of IFN-γ and inhibition of degranulation by TGF-β are well established, we wondered whether TGF-β could also induce immune-regulatory miRNAs in human CD8(+) T cells. We used miRNA microarrays and high-throughput sequencing in combination with qRT-PCR and found that TGF-β promotes expression of the miR-23a cluster in human CD8(+) T cells.

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.

The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine that inhibits T and NK cell responses via the A(2A) adenosine receptor (ADORA2A). This mechanism is used by regulatory T cells (T(reg)) that are associated with increased mortality in OvCA. Immunohistochemical staining of human OvCA tissue specimens revealed further aberrant expression of CD39 in 29/36 OvCA samples, whereas only 1/9 benign ovaries showed weak stromal CD39 expression.

Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe.

The optic lobe forms a prominent compartment of the Drosophila adult brain that processes visual input from the compound eye. Neurons of the optic lobe are produced during the larval period from two neuroepithelial layers called the outer and inner optic anlage (OOA, IOA). In the early larva, the optic anlagen grow as epithelia by symmetric cell division.

GDF-15 contributes to proliferation and immune escape of malignant gliomas.

Purpose: Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.

Experimental Design: The expression of GDF-15 in glioma cell lines was assessed by quantitative reverse transcriptase-PCR and immunoblot.

Transcriptional profiles of CD133+ and CD133- glioblastoma-derived cancer stem cell lines suggest different cells of origin.

Glioblastoma multiforme (GBM) is paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Growing evidence suggests that different types of CSC lead to the formation of GBM. This has prompted the present comparison of gene expression profiles between 17 GBM CSC lines and their different putative founder cells.

Distortion reduction in Slow Light systems based on stimulated Brillouin scattering.

We show a simple method to reduce the distortions in SBS based slow light systems. The distortion reduction is simply based on a broadening and adaptation of the gain bandwidth. However, a broadened gain reduces the achievable fractional delay which cannot be compensated by higher pump powers.

Comparison of delay enhancement mechanisms for SBS-based slow light systems.

We compare two simple mechanisms for the enhancement of the time delay in slow light systems. Both are based on the superposition of the Brillouin gain with additional loss. As we will show in theory and experiment if two losses are placed at the wings of a SBS gain, contrary to other methods, the loss power increases the time delay.

Time delay enhancement in stimulated-Brillouin-scattering-based slow-light systems.

We show a simple method of time delay enhancement in slow-light systems based on the effect of stimulated Brillouin scattering. The method is based on the reduction of the absolute Brillouin gain by a loss produced by an additional pump laser. With this method we achieved pulse delays of nearly 100 ns in a standard single-mode fiber.

Potential ultra wide slow-light bandwidth enhancement.

We describe a method which has the potential to enhance the bandwidth of Brillouin based slow-light delay lines drastically. It is based on the overcompensation of the anti Stokes loss spectrum by additional pump sources. With this method it might be possible to overcome the bandwidth limit of Brillouin scattering which for one pump wave is given by two times the natural Brillouin shift in the incorporated waveguide.