Publications by authors named "Markley S Oliveira-Junior"
Agathisflavone is a flavonoid with anti-neuroinflammatory and myelinogenic properties, being also capable to induce neurogenesis. This study evaluated the therapeutic effects of agathisflavone-both as a pharmacological therapy administered and as an pre-treatment aiming to enhance rat mesenchymal stem cells (r)MSCs properties-in a rat model of acute spinal cord injury (SCI). Adult male Wistar rats ( = 6/group) underwent acute SCI with an F-2 Fogarty catheter and after 4 h were treated daily with agathisflavone (10 mg/kg ip, for 7 days), or administered with a single i.
View Article and Find Full Text PDFLupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors.
Markley Silva Oliveira-Junior Erica Patricia Pereira Vanessa Cristina Meira de Amorim Luã Tainã Costa Reis Ravena Pereira do Nascimento
Int Immunopharmacol
May 2019
Article Synopsis
- Neuroinflammation in the central nervous system, primarily involving astrocytes and microglia, contributes to neuron damage in neurodegenerative disorders like Parkinson's and Alzheimer's disease.
- A study on lupeol, a dietary triterpene with antioxidant properties, found that it provided neuroprotective effects in cerebellar cultures treated with inflammatory agents.
- Lupeol not only changed the morphology of astrocytes to a protective form but also down-regulated pro-inflammatory markers and up-regulated neurotrophic factors, highlighting its potential for mitigating neuroinflammation and promoting neuron health.