Clinical prediction rules for preterm birth in patients presenting with preterm labor.

Objective: To develop prediction rules to identify which women with preterm labor are at greatest risk for delivery within 10 days and before 37 weeks of gestation using demographic and clinical risk factors alone.

Methods: We analyzed data collected for a prospective cohort study of singleton pregnancies at 22-33 6/7 weeks of gestation with preterm labor. Potential risk factors were included in multivariable logistic models for each outcome.

The soluble receptor for advanced glycation end products can prospectively identify patients at greatest risk for preterm birth.

Objective: Our primary objective was to determine whether there was an association between levels of antenatal maternal serum soluble RAGE (sRAGE), drawn at the time of presentation with preterm labor (PTL), and subsequent preterm birth (PTB). Secondary objectives were to determine whether levels of sRAGE - analyzed from both antenatal maternal serum (MS) and postpartum umbilical cord serum (CS) - were associated with neonatal sepsis.

Methods: Nested case-control analyses were performed within a prospective cohort of patients at risk for PTB.