Papillary carcinoma of the male breast: report of a case.

Intracystic papillary carcinoma of the male breast represents an extremely rare entity that accounts for less than 1% of all malignancies, and histologically may range from papillary hyperplasia in gynecomastia to invasive papillary carcinoma. This report presents the case of a 61-year-old Caucasian man who presented with a 5-year history of a centrally located painless swelling of his right breast with occasional nipple discharge. Triple assessment was very helpful in establishing the diagnosis.

Fine needle aspiration cytology in primary breast angiosarcoma: a case report.

Background: Angiosarcoma of the breast is an uncommon, aggressive, vascular tumor. The cytomorphologic features of angiosarcomas have rarely been reported.

Case: The present study describes a case of breast angiosarcoma initially diagnosed by fine needle aspiration cytology.

Primary osteogenic sarcoma of the breast: cytomorphologic study of 3 cases with histologic correlation.

Background: Primary osteogenic sarcomas of the breast are extremely rare neoplasms. The histologic and cytologic features are comparable to those of their soft tissue and skeletal counterparts. To assess the utility of fine needle aspiration (FNA) in preoperative identification of osteogenic sarcomas, we retrospectively reviewed the FNA findings of 3 cases diagnosed in our hospital over 2 1/2 years.

Prognostic impact of Deoxyribonucleic acid (DNA) image analysis cytometry and immunohistochemical expression of Ki67 in surgically resected non-small cell lung cancers.

Background: The aim of the present study was to evaluate the prognostic significance of DNA ploidy and Ki67 expression in non-small cell lung carcinoma (NSCLC).

Methods: This prospective study included 96 patients with stages I-IIIA NSCLC who underwent surgical excision. DNA image analysis cytometry was applied on imprints.

Cytogenetic profile of unknown primary tumors: clues for their pathogenesis and clinical management.

Unknown primary tumors (UPTs) represent an entity of great clinical and biological interest, whose origin cannot be determined even after medical workup. To better understand their pathogenesis by outlining their genetic composition, 20 UPTs were investigated by G-banding, supplemented with Fluorescence In Situ Hybridization and Comparative Genomic Hybridization analyses. The data obtained were sufficient to reach a diagnosis in five cases-four lymphomas and one Ewing sarcoma-demonstrating that in a subset of UPTs, cytogenetics can be an adjunct for differential diagnosis.

The role of sandostatin LAR in treating patients with advanced hepatocellular cancer.

Background/aims: The overexpression of somatostatin receptors in the liver of some patients with hepatocellular carcinoma is well documented. The daily administration of octreotide in patients with advanced hepatocellular carcinoma was shown to have a marginal clinical effectiveness. The aim of the study was to estimate if and to what extent the administration of octreotide long-acting formulation (Sandostatin LAR) improves survival and quality of life in patients with advanced unresectable hepatocellular carcinoma.

Fluorescent location of malignant cells in fine needle aspirates.

Malignant cells in fine needle aspirates possess a cell surface protease which can be targeted with fluorescent affinity probes. Cells with active GB exhibit cell surface fluorescence when stained with such affinity probes. The nuclei of all cells on the slides can be counterstained with a nuclear fluorescent stain.

The diagnostic value of fine needle aspiration cytology in Waldeyer's ring lymphomas.

Fine needle aspiration cytology (FNAC) is a well-established diagnostic technique for tumours in the head and neck area. In recent years FNAC has been established as an accurate and useful method for the diagnosis of nodal malignant lymphoproliferative disease. The purpose of the present study was to determine and evaluate the accuracy of FNAC in the diagnosis of primary malignant lymphoma of Waldeyer's ring.

Evaluation of argyrophilic nucleolar organiser regions (AgNORs) in multiple myeloma.

Aim: To investigate the prognostic value of argyrophylic nucleolar organiser regions (AgNORs) in multiple myeloma.

Methods: Bone marrow aspirates from 55 newly diagnosed patients with multiple myeloma were stained with the one step AgNO3 technique. The mean number of AgNORs in each plasma cell nucleus (AgNOR count) was tested for a possible correlation with other clinical and laboratory variables at presentation (clinical stage, substage, heavy and light chain isotype, haemoglobin concentration, platelet count, marrow infiltration rate, degree of skeletal lesions, M protein concentration, plasma cell morphology, and serum concentrations of calcium, albumin, lactate dehydrogenase, C reactive protein, and beta 2 microglobulin) and with outcome (response to first line treatment, first remission duration, and overall survival).

Fine needle aspiration (FNA) biopsy of primary cutaneous meningioma: report of two cases.

Two cases of primary cutaneous meningioma are described. A male and a female patient, aged 56 and 61 years, respectively, presented each with a solitary subepidermal nodule. The initial diagnosis was established in both patients by application of FNA biopsy.

Cytologically interesting cases of primary skin tumors and tumor-like conditions identified by fine-needle aspiration biopsy.

The aims of this study are to depict the special but constant cytomorphologic features which allow a distinction among grossly similar skin tumors and to show that cytological assessment of many uncommon skin lesions is possible. The fine-needle aspiration findings of 181 cytologically interesting cases of primary skin tumors selected from 2,301 primary skin lesions examined in our department from 1990-1995 are described. Seventy-five cases were cytologically reported as benign and 89 as malignant.

Fine-needle aspiration cytology in tumors and tumor-like conditions of the oral and maxillofacial region: diagnostic reliability and limitations.

Background: Fine-needle aspiration cytology (FNAC) is a well established diagnostic technique. The purpose of the current study was to evaluate its diagnostic accuracy, sensitivity, and specificity in tumors and tumor-like conditions in the oral and maxillofacial region.

Methods: The results of 1022 cases of FNAC performed over a 7-year period (1990-1996) were retrospectively reviewed and analyzed.

Rapid cytological diagnosis of primary skin tumours and tumour-like conditions.

This study presents the results of fine needle aspiration cytology performed on 1,263 skin lesions which were clinically suspicious for neoplasia. The purpose of the study was to investigate the accuracy of fine needle aspiration cytology for the diagnosis of skin tumours and to assess its clinical value. Twenty-one to 27 Gauge needles were used and the specimens were stained by a quick Giemsa stain.

Aspiration biopsy (FNA) in patients with various lung lesions.

Percutaneous fine needle aspiration biopsy for cytologic examination of lung lesions, is an accepted and safe diagnostic procedure, especially in cases of primary and metastatic lung tumors. This study includes 348 cases of patients with 172 cases of primary and 50 cases of metastatic lung tumors, 16 suspicious for malignancy, 49 negative for malignancy (2 false negatives), 9 inconclusive and 52 with inadequate material. In many tumor cases, immunochemistry was performed and the diagnosis was evaluated by comparison of the cytological diagnosis to the histological one.

Sources of discrepancies in the diagnosis of Hodgkin's disease by fine needle aspiration.

The aim of this study was to assess the value of Fine Needle Aspiration (FNA) Cytology in the diagnosis of Hodgkin's Disease (HD) and to identify the sources and nature of the inaccuracies related to this procedure. We retrospectively studied all cases cytologically diagnosed in our laboratory as HD during a five year period (1990-1994). We also traced cases in which FNA cytology failed to reveal HD and where a subsequent HD diagnosis was made by histology.

Factors influencing distant tele-evaluation in cytology, pathology, conventional radiology and mammography.

The present paper summarizes our 1 year's experience with the use of static high resolution videophones (9600 bauds transmission rate, lossless compression, 512 x 512 spatial resolution). The images (n = 610) belong to regular videoconsultation in cytology (160 images), (160 images), pathology (226 images), conventional radiology (50 images) and mammographies (174 images). The results showed an exponential relationship between agreement with 'gold standards' (true diagnosis of the case based on pathology, surgery and follow-up) and the time of training on screen diagnosis (r = 0.

Fine needle aspiration cytology of non-Hodgkin's lymphomas. A morphologic and immunophenotypic study.

To assess the value of fine needle aspiration cytology (FNAC) in the diagnosis of non-Hodgkin's lymphomas (NHL), we retrospectively studied all the cases diagnosed cytologically as NHL in our laboratory during a five-year period (1987-1991). We also traced cases in which FNAC failed to diagnose NHL and where the diagnosis was made subsequently by histopathology. Fine needle aspiration (FNA) was performed on both peripheral/palpable and deeply situated lesions.

The role of fine needle aspiration cytology in the diagnosis of primary skin tumors.

This study presents the results of 544 fine needle aspirations of primary skin tumors, (275 basal cell carcinomas, 186 squamous cell carcinomas, 41 melanomas, 5 Kaposi sarcomas, 1 sebaceous epithelioma, 1 Merkel tumor, 1 glomangiosarcoma and 34 benign tumors). The purpose of the study was to investigate the accuracy of fine needle aspiration cytology for the diagnosis of skin tumors and to assess its clinical value. 21-27 Gauge needles used and the specimens were stained by MGG and Pap methods.

A new look in the management of unresectable primary hepatocellular carcinoma.

From January 1992 to October 1992, nine patients with unresectable primary hepatocellular carcinoma were treated either by liver resection combined with transarterial on-target chemotherapy (n = 4) or by transarterial on-target chemotherapy alone (n = 5). All nine patients were seen with diffuse spread of their disease and were considered as refractory to surgical treatment. The patients who had liver resection combined with alcohol transtumoral injection of the residual tumor in the liver remnant and transarterial lipiodol on-target chemotherapy, responded well and were seen postoperatively with a significant decrease in size of their residual tumor, which was found histologically to have advanced necrotic changes.

Fine needle aspiration of adrenal myelolipoma: a case report.

A case of an adrenal myelolipoma in a 50-year-old woman with endometrial carcinoma is described. The diagnosis was established by computed tomography-guided fine needle aspiration, which is particularly useful for the pre-operative evaluation of adrenal tumours in asymptomatic, high-risk or cancer patients. The criteria used to distinguish extra-adrenal myelolipomas from mass-forming extramedullary haematopoiesis are discussed.

Stimulation of human platelet aggregation by phospholipase-A and a saline "extract" of a polyurethane.

A saline extract of polyurethane (SPU) induces enzymatic conversion of arachidonic acid (either exogenous or released through the action of exogenous phospholipase-A) by activating a hitherto undiscovered labile enzyme, synthetase-alpha which is not blocked by aspirin. Addition of SPU, plus arachidonic acid or SPU plus phospholipase-A to platelet-rich plasma (PRP) triggers a biphasic platelet aggregation. Incubation of SPU with PRP results in activation and exhaustion of synthetase-alpha; this renders platelets refractory to the various aggregating agents.