Publications by authors named "Marketa Fuchs"
Aims: A data-driven cluster analysis in a cohort of European individuals with type 2 diabetes (T2D) has previously identified four subgroups based on clinical characteristics. In the current study, we performed a comprehensive statistical assessment to (1) replicate the above-mentioned original clusters; (2) derive de novo T2D subphenotypes in the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) cohort and (3) describe underlying genetic risk and diabetes complications.
Methods: We used data from n = 301 individuals with T2D from KORA FF4 study (Southern Germany).
Article Synopsis
- Diabetic kidney disease (DKD) is the leading cause of kidney failure, often progressing to end-stage renal disease (ESRD), and is mainly managed through strict blood glucose and blood pressure control.
- The complexities and mechanisms behind DKD are not well understood, hindering the development of effective treatments despite ongoing research.
- This review summarizes recent studies exploring the relationship between high blood sugar, oxidative stress, and cellular dysfunction that contribute to DKD, emphasizing the need for better understanding to create new treatment options.
Although it is well established that genetic factors play an important role in the etiology of autistic disorder (AD), no specific genes have as yet been implicated. Genetic epidemiological data, particularly the sharp fall in concordance rates from monozygotic to dizygotic twins, indicate that the mode of transmission of this disorder is complex and may involve several genes. The 7q31 locus has been repeatedly linked to AD, suggesting that this chromosomal region is likely to harbor a susceptibility gene for AD.
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