Measurement of metabolite levels and treatment-induced changes in hepatic metastases of gastro-esophageal cancer using 7-T phosphorus magnetic resonance spectroscopic imaging.

Methods for early treatment response evaluation to systemic therapy of liver metastases are lacking. Tumor tissue often exhibits an increased ratio of phosphomonoesters to phosphodiesters (PME/PDE), which can be noninvasively measured by phosphorus magnetic resonance spectroscopy (P MRS), and may be a marker for early therapy response assessment in liver metastases. However, with commonly used P surface coils for liver P MRS, the liver is not fully covered, and metastases may be missed.

P MR Spectroscopy in the Pancreas: Repeatability, Comparison With Liver, and Pilot Pancreatic Cancer Data.

Background: Non-invasive evaluation of phosphomonoesters (PMEs) and phosphodiesters (PDEs) by 31-phosphorus MR spectroscopy (P MRS) may have potential for early therapy (non-)response assessment in cancer. However, P MRS has not yet been applied to investigate the human pancreas in vivo.

Purpose: To assess the technical feasibility and repeatability of P MR spectroscopic imaging (MRSI) of the pancreas, compare P metabolite levels between pancreas and liver, and determine the feasibility of P MRSI in pancreatic cancer.

In vivo phosphorus magnetic resonance spectroscopic imaging of the whole human liver at 7 T using a phosphorus whole-body transmit coil and 16-channel receive array: Repeatability and effects of principal component analysis-based denoising.

Quantitative three-dimensional (3D) imaging of phosphorus ( P) metabolites is potentially a promising technique with which to assess the progression of liver disease and monitor therapy response. However, P magnetic resonance spectroscopy has a low sensitivity and commonly used P surface coils do not provide full coverage of the liver. This study aimed to overcome these limitations by using a P whole-body transmit coil in combination with a 16-channel P receive array at 7 T.

A mask-compatible, radiolucent, 8-channel head and neck receive array for MRI-guided radiotherapy treatments and pre-treatment simulation.

Immobilization masks are used to prevent patient movement during head and neck (H&N) radiotherapy. Motion restriction is beneficial both during treatment, as well as in the pre-treatment simulation phase, where magnetic resonance imaging (MRI) is often used for target definition. However, the shape and size of the immobilization masks hinder the use of regular, close-fitting MRI receive arrays.

Maximizing sensitivity for fast GABA edited spectroscopy in the visual cortex at 7 T.

The combination of functional MRI (fMRI) and MRS is a promising approach to relate BOLD imaging to neuronal metabolism, especially at high field strength. However, typical scan times for GABA edited spectroscopy are of the order of 6-30 min, which is long compared with functional changes observed with fMRI. The aim of this study is to reduce scan time and increase GABA sensitivity for edited spectroscopy in the human visual cortex, by enlarging the volume of activated tissue in the primary visual cortex.