Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.

Background And Objectives: Gene promoter hypermethylation is common in colorectal cancer and is associated with transcriptional silencing. However, the clinicopathological significance of p16(INK4a) gene silencing with hypermethylation is unknown. Therefore, the aim of this study was to analyze loss of p16 expression and its relationship to hypermethylation in sporadic colorectal cancer.

The role of hMLH1 methylation in the development of synchronous sporadic colorectal carcinomas.

Purpose: AB. B. subset of sporadic colorectal carcinomas show microsatellite instability, usually as a result of biallelic hMLH1 gene promoter methylation.