Background: When block grafts are harvested intraorally, the donor sites may act as stress concentrators and alter the structural integrity of the mandible.
Purpose: The study aimed to compare displacement and load failure between intact polyurethane mandibular replicas and similar replicas from which blocks were taken at the symphysis or the ramus. It also aimed to identify trends of load failure.
Evidence has shown activation of T and B cells in gingival tissues in experimental models and in humans diagnosed with periodontitis. The results of this adaptive immune response are noted both locally and systemically with antigenic specificity for an array of oral bacteria, including periodontopathic species, e.g.
View Article and Find Full Text PDFJ Biomed Mater Res B Appl Biomater
October 2016
Development of drug-delivery devices typically involves characterizing in vitro release performance with the inherent assumption that this will closely approximate in vivo performance. Yet, as delivery devices become more complex, for instance with a sequential drug release pattern, it is important to confirm that in vivo properties correlate with the expected "programming" achieved in vitro. In this work, a systematic comparison between in vitro and in vivo biomaterial erosion and sequential release was performed for a multilayered association polymer system comprising cellulose acetate phthalate and Pluronic F-127.
View Article and Find Full Text PDFPurpose: Studies have demonstrated an inconsistent association between implant failure and bone mineral density. The prevalence of osteoporosis in US adults has been reported to range from 5% to 10% in women and from 2% to 4% in men. The prevalence of bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) has been reported to range from 0% to 4.
View Article and Find Full Text PDFThe aim of the current study was to elucidate whether there is an association between selected risk factors and implant failure, as determined by patient-reported outcomes. A trained clinician administered a formal survey questionnaire to 415 patients who had received a total of 963 implants through the University of Kentucky College of Dentistry's implant training program. The questionnaire was designed to obtain information about potential risk factors that may affect implant failure.
View Article and Find Full Text PDFThe University of Kentucky College of Dentistry (UKCD) established an implant training program that provides training in the use of a single implant system, evidence-based diagnostic and treatment protocols (standardized work practices), and a total quality management system (Implant Quality Assurance Program). The aim of this study was to assess the programmatic effectiveness of the UKCD implant training program by reporting the success and survival of implants placed, using patient-reported outcomes and comparing them to previously established benchmarks. A total of 415 patients (963 implants) were interviewed, approximately 50 percent of all qualified patients.
View Article and Find Full Text PDFBecause many complex physiological processes are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the objective of the present research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. The polymers used were cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P).
View Article and Find Full Text PDFPeriodontal disease is highly prevalent, with 90% of the world population affected by either periodontitis or its preceding condition, gingivitis. These conditions are caused by bacterial biofilms on teeth, which stimulate a chronic inflammatory response that leads to loss of alveolar bone and, ultimately, the tooth. Current treatment methods for periodontitis address specific parts of the disease, with no individual treatment serving as a complete therapy.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
October 2013
The capacity to quickly regenerate or augment bone lost as a result of resorption is crucial to ensure suitable application of prosthetics for restoring masticatory function. Calcium sulfate hemihydrate (CS)-based bone graft substitute composites containing poly(β-amino ester) (PBAE) biodegradable hydrogel particles were developed to act as a 'tenting' barrier to soft tissue infiltration, potentially providing adequate space to enable vertical bone regeneration. CS has long been recognized as an osteoconductive biomaterial with an excellent reputation as a biocompatible substance.
View Article and Find Full Text PDFJ Evid Based Dent Pract
September 2012
Study Selection Criteria: An electronic search was performed using a priori selection criteria. PubMed, EMBASE, and the Cochrane Central Library were searched. Studies were limited to randomized, controlled trials in which povidone-iodine (PVP-I) was used as an adjunct to conventional SRP in the treatment of chronic periodontitis.
View Article and Find Full Text PDFSalivary biomarker discovery requires identification of analytes with high discriminatory capacity to distinguish disease from health, including day-to-day variations that occur in analyte levels. In this study, seven biomarkers associated with inflammatory and tissue destructive processes of periodontal disease were investigated. In a prospective cohort study design, analyte expression levels were determined in unstimulated whole saliva samples collected on multiple occasions from 30 healthy adults (i.
View Article and Find Full Text PDFBackground: General dental practitioners (GPs) assess the periodontal status of patients and make decisions to treat patients or refer them to a periodontist. There is little information available regarding this process. The purpose of this study is to identify significant factors that GPs consider important in selecting a particular periodontist.
View Article and Find Full Text PDFJ Evid Based Dent Pract
December 2010
Article Title And Bibliographic Information: Systematic review on the effect of rinsing with povidone-iodine during nonsurgical therapy. Sahrmann P, Puhan MA, Attin T, Scmidlin PR. J Periodontal Res 2010;45:153-64.
View Article and Find Full Text PDFThe University of Kentucky College of Dentistry established a formal implant program in 1999. The program utilizes a single system (Straumann) and a team concept in which implants are placed by residents in period ontology or oral and maxillofacial surgery and restored by predoctoral dental students. The program features stringent patient inclusion and exclusion criteria, incremental structured learning experiences, formal standardized protocols, and hands-on preclinical learning experiences.
View Article and Find Full Text PDFJ Long Term Eff Med Implants
June 2011
The feasibility of using preformed calcium sulfate (CS) space-making devices (SMDs) for bone regeneration was explored using a rabbit calvarial model. Twenty-four CS devices were fabricated. Twelve of these were SMDs, which consisted of a domed head that served as the actual space-maker, and a stalk or "tail" portion used to affix the device to the bone.
View Article and Find Full Text PDFBackground: Saliva contains a large number of biomolecules, some of which have putative diagnostic usefulness. A potential problem with the use of biomolecules in diagnosis is day-to-day fluctuation due to within-subject variability. This study evaluated the intraindividual variability of six salivary analytes in healthy adults and determined their normal range.
View Article and Find Full Text PDFThis article reviews the evidence regarding the effectiveness of various patient-applied interventions for dentinal hypersensitivity. Self-applied treatments are popular because they are both economical and easy to use. The disadvantages include compliance, difficulty to deliver to specific sites, slow onset of action, and the requirement for continuous use.
View Article and Find Full Text PDFDentinal hypersensitivity is a common dental complaint, especially in periodontal patients. It is believed to be mediated by a hydrodynamic mechanism in which various stimuli result in increased fluid flow in dentinal tubules, thereby generating action potentials in associated nerve fibers. Although it is often perceived as mild discomfort by the patient, it can be severe.
View Article and Find Full Text PDFEvidence-based medicine requires the integration of best research evidence with the clinician's expertise and the patient's unique values and circumstances. One of the most important issues in deciding what course of treatment to select is balancing the potential risks and benefits of treatment. A framework for evidence-based decision-making includes formulating the clinical question and then retrieving, appraising, and considering the applicability of the evidence to the patient.
View Article and Find Full Text PDFEvidence-based health care seeks to base clinical practice and decision-making on best evidence, while allowing for modifications because of patient preferences and individual clinical situations. Dentistry has been slow to embrace this discipline, but this is changing. In the Graduate Periodontology Program (GPP) of the University of Kentucky, an evidence-based clinical curriculum was implemented in 2004.
View Article and Find Full Text PDFJ Evid Based Dent Pract
December 2008
J Biomed Mater Res B Appl Biomater
February 2009
Calcium sulfate (CS) has enjoyed a longer history of clinical use than most currently available biomaterials. It is well-tolerated when used to fill bone defects and undergoes rapid and complete resorption without eliciting a significant inflammatory response. The raw material from which it is made is relatively inexpensive and abundant.
View Article and Find Full Text PDFBackground: Tumor necrosis factor-alpha (TNF-alpha), C-telopeptide pyridinoline cross-links of type I collagen (ICTP), and receptor activator of nuclear factor-kappa B ligand (RANKL) have been associated with bone remodeling and periodontal tissue destruction. This study evaluated the level of these biomarkers in saliva with respect to periodontal disease status.
Methods: Levels of TNF-alpha in unstimulated whole saliva of 74 adults (35 subjects with moderate to severe periodontal disease and 39 healthy controls) and salivary levels of RANKL and ICTP of a subset of 21 subjects and 21 matched controls were examined using enzyme immunosorbent assays in a case-control clinical study.