Publications by authors named "Mark Tyrrell"

Article Synopsis
  • The study reviews a hybrid management approach for treating large thoracic aortic aneurysms (>80mm), combining endovascular techniques (TEVAR and FBEVAR) with open surgical repair without aortic cross-clamping.
  • Researchers conducted a retrospective analysis of patients who underwent this treatment in two aortic centers from December 2017 to March 2024, focusing on patient outcomes such as survival, complications, and aneurysm size changes.
  • Results showed a 100% survival rate within 30 days post-surgery and successful regression of the aneurysm sac in almost all patients, indicating that this hybrid method is both safe and effective for complex thoracic aneurysms.
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Article Synopsis
  • An observational cohort study was conducted at a tertiary referral center to analyze the medical and surgical characteristics of patients assessed for abdominal aortic aneurysm repair and their 12-month outcomes.
  • Data were collected from patients at an aortic multidisciplinary meeting, revealing that 621 patients were discussed, with 292 undergoing surgery and 138 receiving non-operative management, which had a significantly higher mortality rate at 41%.
  • It was found that non-operative patients generally had more comorbidities, were older, and often lived with frailty, indicating the importance of comprehensive geriatric assessments and shared decision-making in managing asymptomatic aortic aneurysms.
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Article Synopsis
  • The study evaluated how COVID-19 affected the number of patients undergoing two types of surgery for complex aortic aneurysms (cAAs) from 2018 to 2021.
  • It found that while the overall volume of endovascular repairs (ER) remained stable during the pandemic, the case load for open surgical repairs (OSR) significantly decreased.
  • Additionally, ER patients had shorter hospital and ICU stays during the pandemic without negatively impacting their early mortality and morbidity rates.
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Recently published experience has shown that endovascular management of the aortic arch, including sealing in the proximal zones, can be a viable option for patients considered unfit for conventional open repair. Endograft designs vary and include single or multibranch devices, with or without the addition of surgical debranching. Initial reports show that both techniques can be performed with high technical success and acceptable perioperative morbidity and mortality rates in high volume centers.

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Background: Percutaneous endovascular aneurysm repair (PEVAR) is becoming increasingly popular due to fewer access-related complications, shorter procedural times and length of stay (LOS). Our aim was to explore factors associated with access-related complications and their impact on procedural time and LOS.

Methods: We retrospectively analyzed consecutive aorto-iliac endovascular procedures in a tertiary hub comprising 2 institutions and 18 consultant vascular surgeons and interventional radiologists between 2016-2017.

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Summary Background Data: Aneurysms of the arch are a complex clinical problem and a technical challenge. Currently, over 40% of patients are considered unfit for conventional open surgery, requiring a cardiopulmonary bypass and hypothermic circulatory arrest. In experienced hands and appropriate anatomic conditions, arch-branched graft technology has shown to be a safe and effective alternative to open conventional surgery to patients that historically have had no surgical options.

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Objective: Use of colour duplex ultrasound (CDUS) and computed tomography angiography (CTA) for infrarenal endovascular aortic aneurysm repair (EVAR) surveillance differs in internationally published guidelines. This study aimed firstly to compare CDUS detection of significant sac abnormalities with CTA. Secondly, a sensitivity analysis was conducted to compare financial estimates of the, predominantly CDUS based, local and Society of Vascular Surgery (SVS) protocols, the risk stratified European Society of Vascular Surgery (ESVS) protocol, and the CTA based National Institute of Health and Care Excellence (NICE) protocol.

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This article reviews endovascular management of chronic post-dissection aneurysms of the aortic arch. Therapeutic strategies intended for this complex aortic condition are evolving rapidly to allow the treatment of various hostile aortic anatomy and frail patients. Principles, technical considerations, devices and outcomes of each technique are reviewed and summarized.

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Background: Streptococcus pneumoniae is considered a rare cause of mycotic aneurysms. The microbiological diagnosis of mycotic aneurysms can be difficult, and many patients have negative blood culture results.

Methods: We describe a series of four consecutive cases of mycotic aneurysms caused by S.

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Objective: We report our experience of the treatment of postdissection arch aneurysms and thoracoabdominal aortic aneurysms (TAAAs) by endovascular repair using fenestrated and branched endografts.

Methods: This study includes all patients presenting with chronic postdissection aneurysms >55 mm in diameter deemed unfit for open surgery and treated by complex endografting between October 2011 and April 2017. Where appropriate, staged management strategies including left subclavian artery revascularization, thoracic endografting, dissection flap fenestration, and tear enlargement were performed before the complex endovascular repair.

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We report the management of a patient who had an open-surgical repair following traumatic avulsion of the supra-aortic trunks (SAT) 30 years prior to presentation with a large arch aneurysm and poor cerebral collaterals. "Simple" thoracic endovascular aneurysm repair (TEVAR) was not an option because it would have excluded the collateral circulation to the carotid and vertebral arteries. We devised a two-stage hybrid procedure to repair this challenging aneurysm.

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An ageing population that is increasing does not necessarily mean an increase in people who require health and social care. However, it is predicted that a wide range of such services is likely to be needed. This demand is set against a shortage of skilled healthcare professionals and a lack of interest in working with older people.

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Thoracic endografting is widely used in the treatment of complicated acute type B aortic dissections to redirect the entire aortic flow toward the true lumen by covering the proximal entry tear. This procedure is challenging because endovascular navigation, maintaining position in the true lumen, can be difficult as there are frequently numerous reentry tears. There is obvious potential for complications such as malpositioning of the distal part of the endograft within the false lumen.

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Purpose Of Review: The introduction of endovascular techniques and improvements in the medical management of atherosclerotic carotid lesions have led to changes in the modern management of stroke. The purpose of this review is to summarize the latest developments in surgical carotid intervention and highlight the current controversies.

Recent Findings: The predominant controversies that dominate the correct surgical management of carotid atherosclerotic disease are: Notwithstanding the results of the Carotid Revascularisation Endarterectomy versus Stenting Trial, does carotid artery stenting produce equivalent outcomes to surgical carotid endarterectomy? Should recent developments in best medical management of these lesions and changing socioeconomic factors restrict the indication for surgical intervention for asymptomatic lesions? What is the ideal time frame for carotid interventions in symptomatic patients?

Summary: There is insufficient current or historic evidence to resolve these controversies and further large randomized controlled trials are therefore required.

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A 65-year-old man with a tender, 98-mm-diameter, pararenal aortic aneurysm was referred to our center. This patient was unfit for open repair and could not wait 8 weeks for a custom-made endograft to be manufactured. We describe the endovascular treatment of his aneurysm with a 4-branch endograft that had been constructed for another patient.

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Working in emergency departments (EDs) is inherently stressful, and stress caused by events such as witnessed death, elder or child abuse, and aggression and violence can have profound effects on staff. One strategy that can be effective in helping staff deal with such events is critical incident stress debriefing but, as the literature suggests, this is poorly established in ED settings. This article reports the results of a study in three EDs in Ireland of nurses' and doctors' perceived needs for debriefing and makes recommendations to improve this area of practice.

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Until fairly recently, experience with advanced endovascular technologies, including fenestrated endovascular repair (FEVAR), has been limited to a relatively small number of practitioners worldwide. Excellent outcomes have been achieved by these accomplished surgeons who, at least initially, have primarily used custom-made devices constructed by a single endograft manufacturer. Access to this technology has been limited by the skills necessary for such procedures and by the customization process with industry partners.

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Ischaemic stroke represents a major health hazard in the western world, which has a severe impact on society and the health-care system. Roughly, 10% of all first ischaemic strokes can be attributed to significant atherosclerotic disease of the carotid arteries. Correct management of these lesions is essential in the prevention and treatment of carotid disease-related ischaemic events.

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Background: Development in endograft design has extended endovascular treatment to include thoracoabdominal aortic aneurysms (TAAA). We report our experience using fenestrated and branched endografts in the management of TAAA.

Methods: We analyzed a cohort of consecutive patients treated electively for TAAA using endovascular techniques between 2006 and 2011.

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The effects of stressful incidents on emergency department (ED) staff can be profound. Witnessing aggression, violence or the death of patients, or participating in resuscitation, can be emotionally and physically demanding. Despite the frequency of these events, ED staff do not become immune to the stress they cause, and are often ill prepared and under supported to cope with them.

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Objective: To compare the outcomes of 3 upper arm access types: transposed brachiobasilic arteriovenous fistula (BBAVF), autogenous brachial vein-brachial artery access (ABBA), and a new type of ePTFE graft (Flixene™ graft) (AVG), in a consecutive series of patients treated in a tertiary centre.

Methods: A prospective, computerized access database was analysed retrospectively to identify all patients undergoing BBAVF, ABBA, or AVG between January 1, 2008, and December 31, 2009.

Results: A total of 108 patients were identified; of whom 45 had BBAVF, 15 ABBA, and 48 ePTFE brachioaxillary AVG.

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