A stitch in time: unrecognized retained foreign bodies after a needlefish injury.

We present a case report of a traveller injured by a needlefish in the Caribbean. The needlefish leapt from the ocean and struck the traveller's face at high speed, causing a seemingly superficial puncture wound on his nose. Later, it became apparent that multiple fish bones had broken off and lodged in his nasal cavity, very narrowly missing his cribriform plate.

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.

Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41.

Ten-month in vitro leakage study of a single-cone obturation system.

The purpose of this study was to compare the in vitro sealing ability of the continuous wave of condensation technique using gutta-percha and an epoxy resin based sealer, AH Plus to the sealing ability of the single-cone, glass-ionomer-based Activ GP Precision Obturation System over 10 months. Fifty maxillary anterior teeth were randomly divided into 2 test groups (20 canals each) and 2 control groups (5 positive and 5 negative). All teeth were stored in 0.

Surgical trends among endodontists: the results of a web-based survey.

The purpose of this survey was to investigate the frequency and characteristics of surgery among active endodontists in the United States. The survey also inquired about residency and postresidency training in endodontic surgery. A Web-based questionnaire regarding endodontic surgery was distributed via e-mail to 2,532 active members of the American Association of Endodontists in the United States.

The use of intraosseous anesthesia among endodontists: results of a questionnaire.

The purpose of this study was to investigate the use of supplemental intraosseous (IO) anesthesia among endodontists in the United States. The study also looked at the types of anesthetic solutions commonly used for IO anesthesia and in which diagnostic conditions IO anesthesia is used. A Web-based survey of 2,528 active members of the American Association of Endodontists was sent out by e-mail.

Use of the microscope in endodontics: results of a questionnaire.

The purpose of this study was to investigate the frequency and characteristics of operating microscope (OM) utilization among endodontists in the United States. The study also investigated how OM use has changed since a similar study was published nearly a decade ago. A web-based survey regarding OM usage was e-mailed to 2340 active members of the American Association of Endodontists (AAE) in the United States.

In vitro study to compare the coronal microleakage of Tempit UltraF, Tempit, IRM, and Cavit by using the fluid transport model.

An adequate coronal seal is critical for the success of root canal therapy. The purpose of this study was to assess and compare the coronal microleakage of 4 temporary filling materials used to seal the access cavity in root canal treated teeth. Standardized access cavities were prepared in 55 extracted human, single canal teeth.

Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.

The CRF antagonist pharmacophore is a heterocyclic ring bearing a critical hydrogen-bond acceptor nitrogen and an orthogonal aromatic ring. CRFR1 antagonists have shown a 40-fold and 200-fold loss in potency against the CRFR1 H199V and M276I mutant receptors, suggesting key interactions with these residues. We have derived a two component computational model that correlates CRFR1 binding affinity within the reported series to antagoinst/H199 complexation energy and M276 hydrophobic contacts.

A comparison of dental services received by Medicaid and privately insured adult populations.

Background: Few studies have compared differences in dental care utilization rates between a publicly and a privately insured adult population in the same geographic area. The authors conducted this study to compare the demographic characteristics and use of dental services for enrollees in the Iowa Medicaid program and in the Delta Dental Plan of Iowa. The focus was on the overall use of dental services, with an emphasis on the use of tertiary care services such as endodontic therapy and tooth extraction services.