Publications by authors named "Mark Slaughter"

Article Synopsis
  • Recent studies have indicated that mitral valve replacement (MVR) may perform better hemodynamically compared to mitral valve repair (MVr) for ischemic mitral regurgitation, but with no significant survival difference at 2 years.
  • A study analyzed outcomes of 111 patients who underwent either MVr or MVR, finding that although MVR experienced less regurgitation at 1 year, mortality rates between the two groups were similar after 1 and 2 years.
  • The results suggest that MVr may be a viable surgical option for ischemic mitral regurgitation, offering comparable early mortality and mid-term valve performance to MVR.
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Background: Takotsubo syndrome (TTS) is being diagnosed more often with its increased recognition over the past 2 decades and with the availability of imaging such as point-of-care echocardiography and tissue characterization by cardiovascular magnetic resonance (CMR).

Case Summary: A young man developed pericarditis and was treated with steroids. A few weeks later, he suffered classic TTS and then presented a week later with the rare complication of apical myocardial rupture and a left ventricular (LV) pseudoaneurysm.

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  • The study investigates the survival outcomes of multiorgan transplants involving heart donations from both donation after circulatory death (DCD) and donation after brain death (DBD) donors.
  • A total of 1,844 DBD and 91 DCD heart transplant patients were analyzed, focusing on combinations with other organs like kidneys, livers, and lungs.
  • Results showed no significant difference in overall survival rates between DCD and DBD groups, despite longer ischemia times in DCD cases, indicating that DCD organ transplants can be as effective as DBD transplants.
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Purpose: To address the clinical need for totally implantable mechanical circulatory support devices, Bionet Sonar is developing a novel Ultrasonic Transcutaneous Energy Transmission (UTET) system that is designed to eliminate external power and/or data communication drivelines.

Methods: UTET systems were designed, fabricated, and pre-clinically tested using a non-clinical HeartWare HVAD in static and dynamic mock flow loop and acute animal models over a range of pump speeds (1800, 2400, 3000 RPM) and tissue analogue thicknesses (5, 10, 15 mm).

Results: The prototypes demonstrated feasibility as evidenced by meeting/exceeding function, operation, and performance metrics with no system failures, including achieving receiver (harvested) power exceeding HVAD power requirements and data communication rates of 10kB/s and pump speed control (> 95% sensitivity and specificity) for all experimental test conditions, and within healthy tissue temperature range with no acute tissue damage.

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Due to the discrepancy between patients awaiting a heart transplant and the availability of donor hearts, strategies to expand the donor pool and improve the transplant's success are crucial. This review aims to summarize current knowledge on the ex vivo heart preservation (EVHP) experience as an alternative to standard cold static storage (CSS). EVHP techniques can improve the preservation of the donor's heart before transplantation and allow for pre-transplant organ evaluation.

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Purpose: CoRISMA MCS Systems Inc (Hamden CT) is developing an innovative mechanical circulatory support system (CMCS) as a durable therapeutic option for heart failure (HF) patients. The CMCS system is comprised of an axial flow pump, non-contacting hydrodynamic bearings, and integrated DC motor designed to be fully implantable in a left atrial (LA) to aortic (Ao) configuration; this unloading strategy may be particularly beneficial for HF patients with preserved ejection fraction (HFpEF). The small (5.

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Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery.

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Article Synopsis
  • Mechanical unloading with left ventricular assist devices (LVADs) can significantly improve heart function in some advanced heart failure patients, and researchers are studying the related clinical and biological changes.
  • In a study involving 208 patients, a combination of clinical data and RNA sequencing was used to identify predictors of heart recovery after LVAD implantation, focusing on factors like ejection fraction and heart size.
  • The results showed that specific clinical indicators and a biological variable (LRRN4CL) were linked to potential recovery, suggesting that this research could enhance diagnosis and treatment strategies for advanced heart failure.
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We characterize the anatomy and function of never before studied total artificial hearts (TAHs) using established methods for testing mechanical circulatory support (MCS) devices. A historical review of TAHs is also presented to aid in benchmarking performance metrics. Six TAHs, ranging from spooky Halloween beating hearts to a cute colorful plush heart, were imaged, instrumented (mock flow loops) to measure their pressure, volume, and flow, and qualitatively evaluated by 3rd party cardiac surgeons for anatomical accuracy and surgical considerations.

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The shortcomings of expense, power requirements, infection, durability, size, and blood trauma of current durable LVADs have been recognized for many years. The LVADs of tomorrow aspire to be fully implantable, durable, mitigate infectious risk, mimic the pulsatile nature of the native cardiac cycle, as well as minimize bleeding and thrombosis. Power draw, battery cycle lifespan and trans-cutaneous energy transmission remain barriers to completely implantable systems.

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Objectives: Heart transplantation for adult congenital heart disease is complicated and associated with challenging pretransplant support, long waiting and high early post-transplant mortality. We explored if surgical and medical advances and allocation system changes have affected outcomes.

Methods: From United Network for Organ Sharing database, adults with congenital heart disease listed for heart transplantation were queried.

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Penetrating cardiac injuries usually require emergent surgical intervention. Our patient presented to the trauma centre with multiple stab wounds to the neck, chest, epigastric region and abdomen. She arrived haemodynamically stable, and her initial Focused Assessment with Sonography for Trauma exam was negative.

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Background: Aortic aneurysms involving the proximal aortic arch, which require hemiarch-type repair, typically require circulatory arrest with antegrade cerebral perfusion. Left carotid antegrade cerebral perfusion (LCP) via distal arch cannulation without circulatory arrest was used in this study's patient population. The goal was to assess the operative efficiency and clinical outcomes of using a distal arch cannulation technique that would not require any hypothermic circulatory arrest (HCA) time compared with more traditional brachiocephalic artery cannulation with right-sided unilateral antegrade cerebral perfusion (RCP) and HCA.

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Article Synopsis
  • - The study investigates how being ambulatory while on extracorporeal membrane oxygenation (ECMO) affects survival rates for patients on the lung transplant waitlist and after the transplant.
  • - Using the UNOS database, researchers classified patients on ECMO into ambulatory (AMB) and non-ambulatory (nAMB) groups, finding that both AMB groups had better waitlist survival rates than nAMB groups.
  • - After lung transplantation, the one-year survival rates for non-ECMO patients and AMB patients on veno-venous ECMO were similar, suggesting that physical activity during ECMO may enhance transplant outcomes.
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Vein grafts are the most used conduits in coronary artery bypass grafting (CABG), even though many studies have suggested their lower patency compared to arterial alternatives. We have reviewed the techniques and technologies that have been investigated over the years with the aim of improving the quality of these conduits. We found that preoperative and postoperative optimal medical therapy and no-touch harvesting techniques have the strongest evidence for optimizing vein graft patency.

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Mechanical circulatory support for cardiogenic shock complicated by acute severe aortic regurgitation poses a unique challenge for traditional veno arterial extracorporeal membrane oxygenation (ECMO) because of rapidly rising left ventricular pressures accentuated by the increased afterload from retrograde flow in femoral cannulation. This process necessitates rapid left ventricular unloading while also allowing for adequate native left ventricular function. Herein, we describe a case of cardiogenic and septic shock secondary to methicillin-resistant Staphylococcus aureus complicated by acute severe aortic regurgitation temporized by left atrial-veno arterial (LA-VA) ECMO via the Livanova TandemHeart system.

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Clinical predictors of posttransplant graft loss since the United Network for Organ Sharing (UNOS) heart allocation system change have not been well characterized. Single organ adult heart transplants from the UNOS database were identified (n = 10,252) and divided into a test cohort (n = 6,869, 67%) and validation cohort (n = 3,383, 33%). A Cox regression analysis was performed on the test cohort to identify recipient and donor risk factors for posttransplant graft loss.

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Although surgical ablation has been shown to produce excellent outcomes at follow-up for patients with atrial fibrillation who underwent mitral valve replacement/repair (MVR), this procedure is not commonly performed. Our objective was to conduct a systematic review and meta-analysis to evaluate the outcomes of concomitant surgical ablation during MVR. Three databases were systematically reviewed for randomized clinical trials published by August 2022.

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Article Synopsis
  • * A meta-analysis of 10 studies found no significant difference in perioperative mortality between JWs and non-JWs, despite 86% of non-JWs receiving transfusions.
  • * JWs experienced less blood loss and had higher preoperative and postoperative hemoglobin levels, supporting the safety and equivalence of bloodless surgery outcomes; however, more research is needed to understand the long-term effects of reducing transfusions.
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• Rapidly growing cardiac tumors can be benign or malignant. • Rarely, cardiac myxomas may grow rapidly, causing heart failure or obstructive symptoms. • Echocardiography remains the first-line imaging for cardiac tumors.

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Since the time of their invention, implantable continuous flow left ventricular assist devices (LVADs) have improved the quality of life and extended survival for patients with advanced heart failure. The decision surgeons and their physician colleagues make with these patients to undergo implantation must come with full understanding of the immediate, short-term, and long-term implications of such a life-changing procedure. The presence of pathology regarding the aortic, mitral, and tricuspid valves introduces particularly complex problems for the surgical treatment strategy.

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