Publications by authors named "Mark S Watkins"
Toxicol Pathol
February 2020
Article Synopsis
- Daprodustat is a drug aimed at treating anemia in patients with chronic kidney disease by inhibiting prolyl hydroxylase, which stabilizes HIF and boosts erythropoietin production.
- Long-term studies in rats and mice showed no cancerous effects related to daprodustat, although high doses led to significant side effects like increased red blood cell mass and organ congestion.
- The research indicates that the drug and its metabolites do not present a carcinogenic risk at doses meant for human clinical use, despite producing exaggerated pharmacological effects at much higher animal doses.
