Synopsis of recent research by authors named "Mark S Singer"
- Mark S Singer's recent research primarily focuses on the role of the extracellular sulfatase SULF2 in various carcinomas, including cholangiocarcinoma and squamous cell carcinoma of the head and neck, highlighting its involvement in tumorigenesis and progression through modulation of heparan sulfate proteoglycans.
- His studies reveal that SULF2 levels are notably elevated in pathological conditions, such as cholangiocarcinoma and cirrhosis, suggesting its potential as a therapeutic target and biomarker for liver diseases and cancers.
- Additionally, Singer's work explores the mechanisms of lymphocyte trafficking and adhesion, detailing how sulfated glycomolecules, including ligands for L-selectin on high endothelial venules, facilitate immune responses and lymphocyte homing in various inflammatory conditions.
