Publications by authors named "Mark S Jain"
Article Synopsis
- - The angiotensin-converting enzyme (ACE) plays a key role in regulating blood pressure and is linked to various health conditions, particularly cardiovascular diseases and granulomatous diseases, with elevated levels indicating potential health risks.
- - A new method called ACE phenotyping was used to investigate a specific donor's blood, revealing a unique conformational impairment in ACE, which is found in a small percentage of the healthy population and more frequently in patients with kidney issues.
- - The study linked increased ACE activity and a specific M71V genetic mutation to elevated levels of a natural ACE inhibitor and proposed that monitoring ACE conformational changes could also reflect free bilirubin levels in plasma, which has clinical implications for patient health assessments.
Background: Angiotensin-converting enzyme (ACE) metabolizes a number of important peptides participating in blood pressure regulation and vascular remodeling. Elevated ACE expression in tissues (which is generally reflected by ACE in blood) is associated with increased risk of cardiovascular diseases. Elevated ACE in blood is also a marker for granulomatous diseases.
View Article and Find Full Text PDFAn elevated blood angiotensin I-converting enzyme (ACE) supports diagnosis of sarcoidosis and Gaucher disease. However, some ACE mutations increase ACE shedding, and patients with these mutations are therefore at risk of being incorrectly diagnosed with sarcoidosis because of elevated serum ACE levels. We applied a novel approach called "ACE phenotyping" to identify possible ACE mutations in 3 pulmonary clinic patients that had suspected sarcoidosis based on elevated blood ACE levels.
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